Results 101 to 110 of about 187,838 (300)

Prevalence of alkane monooxygenase genes in Arctic and Antarctic hydrocarbon-contaminated and pristine soils [PDF]

open access: yes, 2017
The prevalence of four alkane monooxygenase genotypes (Pseudomonas putida GPo1, Pp alkB; Rhodococcus sp. strain Q15, Rh alkB1 and Rh alkB2; and Acinetobacter sp.
Greer, C.W.   +6 more
core  

Low temperature limits for root growth in alpine species are set by cell differentiation [PDF]

open access: yes, 2017
Plant growth in cold climates is not limited by carbon assimilation (source activity) but rather by reduced carbon investment into new tissues (sink limitation). It has been hypothesized that all cold-adapted plants face similar growth constraints at low
Hiltbrunner, Erika   +2 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Immunogenicity and Protective Effect of Live Cold-Adapted Vaccines against Influenza B after Intranasal Immunization of Mice

open access: yesЭпидемиология и вакцинопрофилактика, 2015
Live attenuated («att») vaccines based on cold-adapted («ca») strains are a promising approach of influenza prophylaxis enhancement, however, effectiveness evaluation as well as interrelation with immunogenicity should be elucidated, especially for ...
O. S. Kashirina, Y. M. Vasiliev
doaj   +1 more source

A Third Variable in Obesity: The Effects of Brown Adipose Tissue on Thermogenesis

open access: yes, 1981
Approaches to weight management which consider only energy intake and/or expenditure do not consistently lead to favorable outcomes. A third variable, thermogenesis, must also be considered in a comprehensive understanding of obesity· Three types of ...
McMinn, Mark R.
core  

Unveiling the factors shaping the distribution of widely distributed alpine vertebrates, using multi-scale ecological niche modelling of the bat Plecotus macrobullaris [PDF]

open access: yes, 2014
Several alpine vertebrates share a distribution pattern that extends across the South-western Palearctic but is limited to the main mountain massifs. Although they are usually regarded as cold-adapted species, the range of many alpine vertebrates also ...
Antton Alberdi   +3 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

A protocol for recording behavioral activity during longevity studies of adult Chironomidae

open access: yesCHIRONOMUS Journal of Chironomidae Research, 2019
A protocol for quantifying behaviors of adult Chironomidae during lab-based longevity studies is described and definitions of 12 behaviors are provided.
Leonard Charles Ferrington
doaj   +1 more source

Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus [PDF]

open access: yes, 2012
For decades, cold-adapted, temperature-sensitive (ca/ts) strains of influenza A virus have been used as live attenuated vaccines. Due to their great public health importance it is crucial to understand the molecular mechanism(s) of cold adaptation and ...
Chursov, Andrey   +6 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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