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Cold-adapted enzymes

Trends in Biotechnology, 1997
It is an article of faith among biochemists and molecular biologists that precious enzymes must be stored on ice. The usual reason given is that, at temperatures around freezing, enzyme activity is minimized and protein stability maximized. There is considerable evidence supporting this, but is it true for all enzymes? What about enzymes from organisms
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Cold-adapted Euplotes Pheromones

European Journal of Protistology, 2003
Species of Euplotes rely on diffusible signal proteins (pheromones) to promote their mitotic reproduction and mating (sexual) phenomena. Two of these pheromones have recently been structurally characterized from an Antarctic species, E. nobilii, and their amino acid sequences (of 52 and 60 residues, and eight cysteines) were found to be closely related
C. ALIMENTI   +3 more
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Cold Adaptation and Thyroid Hormone Metabolism

Hormone and Metabolic Research, 2005
Resting oxygen consumption and energy expenditure is sensitive to slight alterations in thyroid function. This means that timing and magnitude of cold adaptation would to some extent depend on thyroid function. Local thyroid hormone metabolism is important for energy expenditure and dissipation of heat in special tissues.
Laurberg, P.   +2 more
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Cold adaptation in marine organisms

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1990
Abstract Animals from polar seas exhibit numerous so called resistance adaptations that serve to maintain homeostasis at low temperature and prevent lethal freezing injury. Specialization to temperatures at or below 0 °C is associated with an inability to survive at temperatures above 3-8 °C.
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Cold Adaptation of Triosephosphate Isomerase

Biochemistry, 2017
The main problem for enzymes from psychrophilic species, which need to work near the freezing point of liquid water, is the exponential decay of reaction rates as the temperature is decreased. Cold-adapted enzymes have solved this problem by shifting the activation enthalpy-entropy balance for the catalyzed reaction compared to those of their ...
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Cold adaptation and the human face

American Journal of Physical Anthropology, 1970
AbstractA framework is suggested within which the evolutionary biology of the human head and face can be explored; it includes several channels of natural and behavioral selection as well as modes of “plasticity” change.One aspect of the model is then examined by means of physiological and anthropometric experimentation.
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Cold-Adapted and Mesophilic Brachyurins

Biological Chemistry, 2002
Two different types of brachyurins, termed I and II, have been described in the literature. Within type I there are two subtypes, Ia and Ib. The prototype for the type I brachyurins is Fiddler crab collagenase I. Its cold-adapted analogue from Antarctic krill, termed euphaulysin, shares many of its characteristics.
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Cold-Adapted Enzymes

2001
In the last few years, increased attention has been focused on enzymes produced by cold-adapted micro-organisms. It has emerged that psychrophilic enzymes represent an extremely powerful tool in both protein folding investigations and for biotechnological purposes. Such enzymes are characterised by an increased thermosensitivity and, most of them, by a
D. Georlette   +12 more
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Cold Adaptation in DEAD-Box Proteins

Biochemistry, 2010
Spontaneous rearrangements of RNA structures are usually characterized by large activation energies and thus become very slow at low temperatures, yet RNA structure must remain dynamic even in cold-adapted (psychrophilic) organisms. DEAD-box proteins constitute a ubiquitous family of RNA-dependent ATPases that can often unwind short RNA duplexes in ...
Gwendoline, Cartier   +4 more
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Cold Adaptation of Enzyme Reaction Rates

Biochemistry, 2008
A major issue for organisms living at extreme temperatures is to preserve both stability and activity of their enzymes. Cold-adapted enzymes generally have a reduced thermal stability, to counteract freezing, and show a lower enthalpy and a more negative entropy of activation compared to mesophilic and thermophilic homologues.
Sinisa, Bjelic   +2 more
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