Results 41 to 50 of about 189,516 (294)

Biodegradation of phenol by cold-adapted bacteria from Antarctic soils

Polar Biology, 2017
Phenol is an important pollutant widely discharged as a component of hydrocarbon fuels, but its degradation in cold regions is a great challenge due to the harsh environmental conditions. To date, there is little information available concerning the biodegradation of phenol by indigenous Antarctic bacteria.
Lee, Gillian Li Yin, Ahmad, Siti Aqlima, Yasid, Nur Adeela, Zulkharnain, Azham, Convey, Peter, Johari, Wan Lutfi Wan, Alias, Siti Aisyah, Gonzalez-Rocha, Gerardo, Shukor, Mohd Yunus   +8 more
openaire   +4 more sources

Aliivibrio wodanis as a production host: development of genetic tools for expression of cold-active enzymes

Microbial Cell Factories, 2019
Background Heterologous production of cold-adapted proteins currently represents one of the greatest bottlenecks in the ongoing bioprospecting efforts to find new enzymes from low-temperature environments, such as, the polar oceans that represent ...
Jenny Johansson Söderberg, Miriam Grgic, Erik Hjerde, Peik Haugen   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

An overview of the biotechnological applications of bacterial cold active enzymes

Environment Conservation Journal, 2015
Bacteria are adapted to survive at extremely low temperatures due to their exceptionally versatile metabolic capabilities. Besides other metabolites, a number of cold active enzymes are also produced by these tiny organisms to make their survival ...
A.S. Panwar, D. Molpa, G.K. Joshi
doaj   +1 more source

Detailed Structural Characterization of the Lipooligosaccharide from the Extracellular Membrane Vesicles of Shewanella vesiculosa HM13

Marine Drugs, 2020
Bacterial extracellular membrane vesicles (EMVs) are membrane-bound particles released during cell growth by a variety of microorganisms, among which are cold-adapted bacteria.
Rossella Di Guida, Angela Casillo, Fumiaki Yokoyama, Jun Kawamoto, Tatsuo Kurihara, Maria Michela Corsaro   +5 more
doaj   +1 more source

Origin of Life

, 2012
The evolution of life has been a big enigma despite rapid advancements in the fields of biochemistry, astrobiology, and astrophysics in recent years.
A. Gibbons, Ashwini Kumar Lal, C. Bohler, C. Chyba, C. Huber, C.E. Manning, C.J. Salter, D. Penny, D. Warmflash, D.S. Heckman, D.S. Mckay, E.G. Roussel, F. Hoyle, F. Hoyle, F. Hoyle, G.F. Joyce, H.C. Arp, H.C. Urey, J. Li, J. Maddox, J. Postgate, J.B.S. Haldane, J.K. Fredrickson, J.V. Narlikar, J.W. Schopf, K. Kvenvolden, L.-H. Lin, L.E. Orgel, L.J. Richardson, M.T. Mondigan, N.C. Wickramsinghe, P. David, P. Ehrenfreund, P. Senapathy, R. Shapiro, R.D. Lorenz, S Arrhenius, S.J. Mojzsis, S.L. Miller, S.L. Miller, Stofan, T. Brock, T.D. Brack, W. Gilbert, W. Martin, Y.-J. Kuan, Y.-J. Ma   +46 more
core   +1 more source

The genome and transcriptome of Trichormus sp NMC-1: insights into adaptation to extreme environments on the Qinghai-Tibet Plateau [PDF]

, 2016
The Qinghai-Tibet Plateau (QTP) has the highest biodiversity for an extreme environment worldwide, and provides an ideal natural laboratory to study adaptive evolution.
A Stamatakis, A Zorina, AL Delcher, B Langmead, BA Methé, C Xie, DA Los, DJ Wright, EP Balskus, G Blanc, G Norsang, HÄ Suh, J Qi, J Qi, J Zhang, JF Hess, JI Carreto, JM Shick, JP Zehr, K Mavromatis, KS Siddiqui, L Li, L R, L Ran, M Borodovsky, M Dassanayake, M Li, M Suyama, N Myers, P Pereira, P Puigbò, P Rajaniemi, PH Sudmant, PM Shih, Q Qiu, Q Tang, R Cavicchioli, RC Edgar, RL Tatusov, S Richter, SP Singh, SP Singh, SP Singh, T De Bie, T Kaneko, T Kogej, T Shi, U Consortium, U Nübel, WM Fitch, Z Xu, Z Yang, Z Yang, ZA Cheviron   +53 more
core   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Bioactive Molecules from Extreme Environments

Marine Drugs, 2020
Marine organisms inhabiting extreme habitats are a promising reservoir of bioactive compounds for drug discovery. Extreme environments, i.e., polar and hot regions, deep sea, hydrothermal vents, marine areas of high pressure or high salinity, experience ...
Daniela Giordano
doaj   +1 more source

Compounding Effects of Climate Warming and Antibiotic Resistance. [PDF]

, 2020
Bacteria have evolved diverse mechanisms to survive environments with antibiotics. Temperature is both a key factor that affects the survival of bacteria in the presence of antibiotics and an environmental trait that is drastically increasing due to ...
Cruz-Loya, Mauricio, Lozano-Huntelman, Natalie, Rodríguez-Verdugo, Alejandra, Savage, Van, Yeh, Pamela   +4 more
core   +1 more source