Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Investigation of cold formed steel angle compression through high throughput design FEA and machine learning. [PDF]
Thangavel P +5 more
europepmc +1 more source
Analysis of cold formed high strength steels in weld area [PDF]
Martin Werunský
openalex +1 more source
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Utilization of cold-formed steel-framed emergency shelter for typhoon reliefs in the Philippines. [PDF]
Valerio DN +6 more
europepmc +1 more source
Mechanical behaviour of connections for cold-formed steel-glass shear wall panels
Bert Van Lancker +2 more
openalex +2 more sources
Design of cold-formed ferritic stainless steel RHS perforated beams
Zixuan Chen, Yuner Huang, Ben Young
openalex +2 more sources
Experimental response of connections between cold-formed steel profile and cement-based panel
The seismic response of sheathed cold-f ormed steel (CFS) structures is highly influenced by the shear behaviour of panel-to-steel framing connections.
LANDOLFO, RAFFAELE +2 more
core
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
Experimental and numerical investigation of a cold-formed steel system used to restore old buildings floor. [PDF]
Fahmy AS +3 more
europepmc +1 more source

