Results 61 to 70 of about 2,080,475 (297)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

A Hybrid Physics-Informed ML Framework for Emission and Energy Flow Prediction in a Retrofitted Heavy-Duty Vehicle

Algorithms
This study introduces a physics-informed machine learning framework for predicting transient emissions and energy variables in a retrofitted heavy-duty diesel vehicle.
Talha Mujahid, Teresa Donateo, Pietropaolo Morrone   +2 more
doaj   +1 more source

An Experimental Investigation on Low Load Combustion Stability and Cold-Firing Capacity of a Gasoline Compression Ignition Engine

Engineering, 2019
Gasoline compression ignition (GCI) is one of the most promising combustion concepts to maintain low pollutant emissions and high efficiency. However, low load combustion stability and firing in cold-start operations are two major challenges for GCI ...
Lei Zhou, Jianxiong Hua, Haiqiao Wei, Yiyong Han   +3 more
doaj   +1 more source

Representation Learning for cold-start recommendation

, 2014
A standard approach to Collaborative Filtering (CF), i.e. prediction of user ratings on items, relies on Matrix Factorization techniques. Representations for both users and items are computed from the observed ratings and used for prediction. Unfortunatly, these transductive approaches cannot handle the case of new users arriving in the system, with no
Contardo, Gabriella, Denoyer, Ludovic, Artières, Thierry   +2 more
openaire   +4 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

COCOA: cold start aware capacity planning for function-as-a-service platforms [PDF]

, 2020
Function-as-a-Service (FaaS) is increasingly popularin the software industry due to the implied cost-savings in event-driven workloads and its synergy with DevOps.
Gias, Alim, Gias, A., Casale, Giuliano, Casale, G., Giuliano Casale, Gias, Alim Ul, Alim Ul Gias, Gias, A.U.   +7 more
core   +1 more source

Cold-start playlist recommendation with multitask learning [PDF]

, 2018
Playlist recommendation involves producing a set of songs that a user might enjoy. We investigate this problem in three cold-start scenarios: (i) cold playlists, where we recommend songs to form new personalised playlists for an existing user; (ii) cold users, where we recommend songs to form new playlists for a new user; and (iii) cold songs, where we
Dawei Chen, Cheng Soon Ong, Aditya Krishna Menon   +2 more
openaire   +3 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source