Results 221 to 230 of about 2,553,529 (294)

Pharmacokinetic and pharmacodynamic interaction of enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, with glimepiride and metformin in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, is expected to be coadministered with antihyperglycaemic drugs with different mechanisms of action. This study aimed to investigate the pharmacokinetic (PK) and pharmacodynamic (PD) interactions between enavogliflozin, glimepiride and metformin.
Kyungrin Chang, Yoonjin Kim, Daye Jung, Jae Min Cho, Joo‐Youn Cho, SeungHwan Lee   +5 more
wiley   +1 more source

From Product Availability to Population Protection: Vaccine Deployment Readiness in Sierra Leone. [PDF]

Ann Glob Health
Ikoona EN, Namulemo L, Ikoona R, Kaluya R, Vandi MA, Sahr F.   +5 more
europepmc   +1 more source

The placental transfer of nirmatrelvir using the ex vivo human placental perfusion model

British Journal of Clinical Pharmacology, EarlyView.
Aims Nirmatrelvir is an effective therapeutic option for COVID‐19 infection and is often administered after symptom onset in pregnant individuals, but few data are available on the associated fetal exposure. The placental perfusion model evaluates maternal–fetal drug transfer across the human placenta and thus can determine fetal drug exposure.
Magdalene Zabek, Eddie Chan, Yong Jin Lim, Bradley L. Urquhart, Facundo Garcia‐Bournissen, Janine R. Hutson   +5 more
wiley   +1 more source

Smart library personalized resource proactive recommendation system integrating user profiling and knowledge graphs. [PDF]

Sci Rep
Xu F.
europepmc   +1 more source

A multi-task heterogeneous graph learning with cross-attention fusion for robust recommendation. [PDF]

Sci Rep
Nazari A, Mansoorizadeh M, Khotanlou H.
europepmc   +1 more source

The absence of women's scientific contributions in core UK pre‐university science qualifications

British Educational Research Journal, EarlyView.
Abstract Despite their groundbreaking contributions to our understanding of the natural world and the universe, women's roles in biology, chemistry, physics, astronomy, environmental science and geology remain largely absent from standard educational specifications in the United Kingdom (UK), particularly at Key Stage 4 (KS4) and Key Stage 5 (KS5), or ...
G. J. Cooke, S. B. White, S. Buttigieg, N. Lowson, S. Galaudage, A. Battisti, L. Kelsey, K. Ross   +7 more
wiley   +1 more source

Cold Tolerance in Alfalfa: Physiological Mechanisms, Regulatory Networks, and Molecular Breeding Prospects. [PDF]

Plants (Basel)
Yang W, Shi X, Lu J, Liu X.
europepmc   +1 more source

Magnetoelastic Cell Monitoring System for Evaluating the Effects of Surface Chemistry on the Performance of Mesenchymal Stem Cell Growth

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The recent clinical adoption of cell therapies has increased the need for more efficient, robust, and reproducible manufacturing technologies. Human mesenchymal stromal cells (hMSCs), a major component of the cell and immunotherapeutic market, remain challenging to manufacture at scale because they require surface attachment and are highly ...
William S. Skinner, Carolina Rivera‐Crespo, Eyerusalem A. Gebreyesus, Said Cifuentes, Samantha Tan, Tristen Douglas, Maribella Domenech‐Garcia, Keat Ghee Ong   +7 more
wiley   +1 more source

A social recommendation model based on adaptive residual graph convolution networks. [PDF]

PeerJ Comput Sci
Chen R, Pang K, Liu Q, Zhang L, Wu H, Tang C, Li P.   +6 more
europepmc   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source