Results 121 to 130 of about 2,154,939 (308)

The Sympathetic Nervous System in Short-Term Adaptation to Cold

open access: yes, 1971
Rats were adapted to cold by 10-min exposure to −20 °C every hour during daytime for a total of 27 exposures over a period of 3 days. The significant delayed hypothermia observed in these adapted animals when exposed to severe cold (−16 °C) for 4 h was ...
G. Oakson   +3 more
core   +1 more source

Prostate Cancer Patient‐Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)‐Based Personalized Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran   +15 more
wiley   +1 more source

Valuing adaptation under rapid change [PDF]

open access: yes, 2013
The methods used to plan adaptation to climate change have been heavily influenced by scientific narratives of gradual change and economic narratives of marginal adjustments to that change.
Celeste Young   +2 more
core  

In vivo comparative analysis of live influenza vaccine candidates obtained by reverse genetics and classical reassortment

open access: yesИнфекция и иммунитет
Difficulties identified in recent years while preparing reassortant live influenza vaccine (LAIV) strains related to the specific biological properties of currently circulating epidemic influenza viruses, necessitate the search for alternative ...
Natalie V. Larionova   +6 more
doaj   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn   +6 more
wiley   +1 more source

Decision-making for climate change adaptation: A systems thinking approach [PDF]

open access: yes, 2013
The impacts of climate change are exacerbated by inefficient adaptation and mitigation decision making, due to the complexity of the decision-making environment. As a consequence, there is no single approach to planning and decision making.
Kambiz Maani, Maani, Kambiz
core  

Biochemical Properties of Collagen from Four Flatfish Species in Cold Area: In Relation to Physiological Temperature and Amino Acid Composition

open access: yesFishes
Collagen (ASC) was purified from four flatfish species (Greenland halibut, blackfin flounder, stone flounder, and slime flounder) collected from a cold area in Japan to investigate their biochemical properties.
Tetsuro Sugai   +2 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

open access: yesAdvanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu   +4 more
wiley   +1 more source

Widely Targeted Metabolomics and Transcriptomics Analysis of the Response and Adaptation Mechanisms of Trifolium ambiguum to Low-Temperature Stress

open access: yesAgronomy
Caucasian clover (Trifolium ambiguum M.Bieb.) is a perennial legume known for its exceptional cold tolerance, commonly used in agriculture and ecosystems in cold climates.
Kefan Cao   +5 more
doaj   +1 more source

Engineering Antigen Density on M13 Bacteriophage for Personalized Nanovaccine

open access: yesAdvanced Healthcare Materials, EarlyView.
Increasing antigen density on the phage capsid impacts phage uptake and antigen cross‐presentation by antigen‐presenting cells, leading to enhanced activation of antitumor CD8+ T cells in the draining lymph nodes. These activated CD8+ T cells subsequently recognize the antigen‐expressing tumors and mediate their specific cytotoxic killing, thereby ...
Shengnan Huang   +7 more
wiley   +1 more source

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