Results 151 to 160 of about 60,419 (262)

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Understanding the Causes of High Organic Matter with Low Bioavailability in Cold-Zone Lake Water: A Case in Hulun Lake. [PDF]

Toxics
Tao Y.
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Spontaneous electro-weak symmetry breaking and cold dark matter

, 2007
In the standard model, the weak gauge bosons and fermions obtain mass after spontaneous electro-weak symmetry breaking, which is realized by one fundamental scalar field, namely the Higgs field.
Zhu Shou-Hua
core  

Environmental Changes During the Late Glacial and Early Holocene Transition Revealed by Palaeolimnological Record from Southern Lithuania. [PDF]

Biology (Basel)
Kluczynska G, Gastevičienė N, Šeirienė V.   +2 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

A prototype differential atom interferometer for fundamental physics. [PDF]

Nature
Baynham CFA, Hobson R, Buchmüller O, Evans D, Hawkins L, Iannizzotto Venezze L, Josset A, Lee D, Pasatembou E, Sauer BE, Tarbutt MR, Walker T, Ennis O, Chauhan U, Brzakalik A, Dey S, Hedges S, Stray B, Langlois M, Bongs K, Hird T, Lellouch S, Holynski M, Bostwick B, Chen J, Eyler Z, Gibson V, Harte TL, Hsu CC, Karzazi M, Lu C, Millward B, Mitchell J, Mouelle N, Panchumarthi B, Scheper J, Schneider U, Su X, Tang Y, Tkalčec K, Zeuner M, Zhang S, Zhi Y, Badurina L, Beniwal A, Blas D, Carlton J, Ellis J, McCabe C, Parish G, Govardhan DP, Vaskonen V, Bowcock T, Bridges K, Carroll A, Coleman J, Elertas G, Hindley S, Metelko C, Throssell H, Tinsley JN, Bentine E, Booth M, Bortoletto D, Callaghan N, Foot C, Gómez-Monedero C, Hughes K, James A, Leese T, Lowe A, March-Russell J, Sander J, Schelfhout J, Shipsey I, Weatherill D, Wood D, Balashov SN, Bason MG, Hussain K, Labiad H, Majewski P, Marchant AL, Newbold D, Pan Z, Tam Z, Thornton TC, Valenzuela T, van der Grinten MGD, Wilmut I, Clarke K, Vick A, AION Collaboration.   +92 more
europepmc   +1 more source

Time‐Multiplexed Organic Electrochemical Transistor for Saliva‐Based Rapid Detection of Viral Proteins

Advanced Science, EarlyView.
A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang, Yuxiang Ren, Shofarul Wustoni, Atheer Alqatari, Adel Hama, Yazhou Wang, Long Chen, Jessica Parrado Agudelo, Luca Salvigni, Keying Guo, Ashraf Dada, Stefan T. Arold, Raik Grünberg, Sahika Inal   +13 more
wiley   +1 more source