Results 291 to 300 of about 678,119 (336)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Repository for extended dark matter object constraints. [PDF]

Eur Phys J C Part Fields
Croon D, Sevillano Muñoz S.
europepmc   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

Quantum sensing for NASA science missions. [PDF]

EPJ Quantum Technol
Mercer CR, Montbach EN, Christe SD, Connerton RM, Podolski DA, Robinson MP, Perez MR.   +6 more
europepmc   +1 more source

TREM2‐Mediated Cholesterol Efflux in Macrophages Inhibits Anti‐Tumor Immunity via Limitation of CD4+ T and NK Cells

Advanced Science, EarlyView.
Impaired anti‐tumor immunity is mediated by TREM2 + macrophages in non‐small cell lung cancer. TREM2 + macrophages prevent anti‐tumor immunity depending on the limitation of CD4 + T and NK cells. TREM2 promotes cholesterol efflux via ABCA1 to limit the production of CX3CL1 in macrophages.
Yunhan Wang, Weina Yu, Xinxin Wang, Qitai Zhao, Qingyang Lei, Aitian Li, Shasha Liu, Tian Wang, Li Yang, Yi Zhang   +9 more
wiley   +1 more source

Photodegradation Driven by Visible Light Exceeds Biodegradation across a Range of Environmental Conditions during the Initial Hours after an Oil Spill. [PDF]

Environ Sci Technol
Ortmann AC, Robinson B, Poon HY, King TL.   +3 more
europepmc   +1 more source

Intraspecific support for the climate variability hypothesis: oxidative damage in lizards after acute temperature exposure. [PDF]

J Exp Biol
Haussmann BD, Joseph NA, Hegdahl TR, Lichtner KE, Woldebirhan RN, Travis BG, Peterson GP, Robbins TR, Haussmann MF.   +8 more
europepmc   +1 more source

Search of high-frequency variations of fundamental constants using spin-based quantum sensors. [PDF]

Natl Sci Rev
Kong X, Zhang Y, Ji C, Chang S, Chen Y, Bian X, Duan CK, Huang P, Du J.   +8 more
europepmc   +1 more source

The reproduction of fire-born soot for comparative cleaning tests on heritage objects. [PDF]

NPJ Herit Sci
Yang N, Cremonesi M, Markevicius T, Del Favo A, Shumikhin K, Ducoli E, Rocha Pires C, Fontana R, Van Der Voort P, Leus K, Nuyts G, Pastorelli G, Jensen SW, Bonaduce I, van den Berg KJ, Morent R, Nikiforov A, Van der Snickt G.   +17 more
europepmc   +1 more source

Photosynthetic Electron Transport in Winter Wheat: Responses to Low-Temperature and Weak-Light Condition. [PDF]

Cells
Yang C, Liu M, Du S, Zhang D, Li X, Wu L, Shi Y, Fang B, Yan G, Wei F.   +9 more
europepmc   +1 more source