Results 41 to 50 of about 23,904 (294)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Frost Hardiness of Iraqi Wheat genotypes [PDF]

, 2015
Frost hardiness level in winter cereals is especially temperature dependent. The low temperature which kills 50% of plants (LT50) is considered to be a standard indicator of frost hardiness level of plant. Frost hardiness is considered the most important
Al-Issawi, M, Fuller, MP, Mahdi, UH, Rihan, HZ   +3 more
core   +1 more source

The effect of landscape complexity and microclimate on the thermal tolerance of a pest insect [PDF]

, 2017
Landscape changes are known to exacerbate the impacts of climate change. As such, understanding the combined effect of climate and landscape on agroecosystems is vital if we are to maintain the function of agroecosystems.
Alford, Lucy, Burel, Françoise, Pierre, Jean-Sébastien, Tougeron, Kévin, van Baaren, Joan   +4 more
core   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Effect of Foliar Application of Potassium Fertilizer on Yield, Fruit Quality, and Cold Hardiness of Vitis spp. ‘Chambourcin’

International Journal of Fruit Science
Temperate regions experiencing sub-zero temperatures negatively impact grapevine yield. Potassium has been claimed as a cryoprotectant to improve cold hardiness in grapevine.
Gurkirat Singh, Andrea R. Gschwend, Imed E. Dami   +2 more
doaj   +1 more source

Agro-Ecological Zoning for Tall Wheatgrass (Thinopyrum Ponticum) as a Potential Energy and Forage Crop in Salt-Affected and Dry Lands of Argentina [PDF]

, 2017
Thinopyrum ponticum, is the most disseminated halophyte speciescultivated for forage on hydro-halomorphic soils in the world. Theobjective of the present work was to identify the geographicareas fordevelopment of tall wheatgrass on halomorphic soils in ...
Falasca, Silvia Liliana, Miranda del Fresno, Ma. Carolina, Pitta Alvarez, Sandra Irene   +2 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bromegrass in Alaska. I.Winter Survival and Forage Productivity of Bromus Species, Types, and Cultivars as Related to Latitudinal Adaptation [PDF]

, 1992
This report summarizes seven separate field experiments, conducted over more than two decades at the University of Alaska’s Matanuska Research Farm, that compared strains within three bromegrass (Bromus) species for winter hardiness and forage ...
Helm, D. J., Klebesadel, Leslie J.
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