Results 71 to 80 of about 786,625 (262)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Application of ABA and ACC in Autumn Affects Dormancy and Cold Hardiness of Pear (Pyrus communis)

HortTechnology
Dormancy in fruit trees is a crucial process that involves many molecular and physiological mechanisms to protect plant organs from abiotic stresses throughout the winter months.
Kelsey D. Galimba, Mackenzie Denew, Jessica M. Waite   +2 more
doaj   +1 more source

Japan-China Collaborative research of terrestrial biology at Great Wall Station, King George Island in 1989/90

Antarctic Record, 1990
The collaboration between Japanese and Chinese biologists has started from the 1988/89 season with a three-year program at Great Wall Station, King George Island.
Yoshikuni Ohyama, Kimio Shimada
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Cold Hardiness in the Genus Rhododendron

Journal of the American Society for Horticultural Science, 1986
Abstract Cold hardiness of 101 Rhododendron genotypes was assessed. In hardy rhododendrons, the difference in hardiness between floral primordia and other tissues or organs was greater than in the less hardy species.
A. Sakai, L. Fuchigami, C.J. Weiser
openaire   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Cold Hardiness Data

, 2018
Author: Jaime Sebastian Azconaemail: jaime4@ualberta.caPublication: Sebastián-Azcona J, Hamann A, Hacke U, Rweyongeza D (2018). Survival, growth and cold hardiness tradeoffs in white spruce populations: implications for assisted migration. Forest Ecology
Jaime Sebastian Azcona (5906030)
core   +1 more source

Revisiting plant hardiness zones to include multiple climatic stress dimensions

iScience
Summary: A tradition exists for delineating “hardiness zones” for important plants in horticulture and agriculture. However, these zones are typically based on surviving cold winter conditions, disregarding other stressors. Factors such as the effects of
Narayani Barve, Uzma Ashraf, Vijay Barve, Marlon E. Cobos, Claudia Nuñez-Penichet, A. Townsend Peterson   +5 more
doaj   +1 more source

Cold Hardiness of Woody Plants

Arnoldia, 1973
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +2 more sources

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source