Results 121 to 130 of about 1,125,979 (313)

Topical capsaicin application causes cold hypersensitivity in awake monkeys

Journal of Oral Science, 2008
Recent animal studies have demonstrated that many trigeminal ganglion neurons co-express TRPV1 and TRPA1 receptors following peripheral inflammation. In the present study, we examined whether cold receptors were sensitized by capsaicin in awake monkeys.
Hiroshi, Kamo, Kuniya, Honda, Junichi, Kitagawa, Yoshiyuki, Tsuboi, Masahiro, Kondo, Masato, Taira, Akiko, Yamashita, Narumi, Katsuyama, Yuji, Masuda, Takafumi, Kato, Koichi, Iwata   +10 more
openaire   +3 more sources

Poly(2‐Oxazoline)‐Based Polyphotoacids: Synthesis, Solution Behavior, and Cellular Uptake of Multi‐Responsive Intracellular Transporters

Macromolecular Rapid Communications, EarlyView.
The ability of photoacids to increase their acidity in response to light irradiation (excited state proton transfer, ESPT) makes them attractive building blocks for the design of stimuli‐responsive copolymers. In this contribution, we present highly biocompatible polyphotoacids based on poly(2‐oxazoline)s bearing 1‐hydroxypyrene units. Low cytotoxicity,
Leonid I. Kaberov, Amod Godbole, Laura Klement, Sreevalsan Achikkulathu, Avinash Chettri, Benjamin Dietzek‐Ivanšić, Carsten Hoffmann, Felix H. Schacher   +7 more
wiley   +1 more source

Artificial light at night alters progression of cold neuropathy in a sex-dependent manner in a mouse model of type II diabetes mellitus

Frontiers in Photonics
Artificial light at night (ALAN) is a pervasive circadian rhythm disruptor. Exposure to ALAN is associated with detrimental effects on physiology and behavior, including disrupted metabolism, immune function, endocrine function, and pain behavior.
Jacob R. Bumgarner, Rhett C. White, Jordan A. Brown, Randy J. Nelson   +3 more
doaj   +1 more source

Functional bowel disease : a challenging frontier in gastroenterology [PDF]

, 1999
The last 30 years have seen incredible advances in the science and practice of gastroenterology and hepatology. In the 1970s, the fiberoptic endoscopic revolution facilitated the visualization of the mucosa of a large segment of the gastrointestinal ...
Camilleri, Michael
core  

Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain [PDF]

, 2011
Background: Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain.
Allchorne, Andrew J, Beggah, Ahmed T, Decosterd, Isabelle, Pertin, Marie, Woolf, Clifford   +4 more
core   +1 more source

Phytochemicals of Cinnamomi Cortex: Cinnamic Acid, but not Cinnamaldehyde, Attenuates Oxaliplatin-Induced Cold and Mechanical Hypersensitivity in Rats

Nutrients, 2019
A chemotherapy drug, oxaliplatin, induces cold and mechanical hypersensitivity, but effective treatments for this neuropathic pain without side effects are still lacking.
H. Chae, Woojin Kim, S. K. Kim
semanticscholar   +1 more source

A Non‐Antigenic Randomized Polyethylene Glycol/Poly(2‐Phenyl‐2‐Oxazine)‐Based Drug Delivery Platform

Macromolecular Rapid Communications, EarlyView.
Randomized PEG (rPEG), a conceptually new PEG alternative, is combined with poly(2‐phenyl‐2‐oxazine) (PPheOzi) to establish an rPEG‐b‐PPheOzi‐b‐rPEG micellar drug delivery platform. The PPheOzi block enables high drug loadings, while competitive ELISA reveals a drastic reduction in anti‐PEG antibody affinity of rPEG in comparison to PEG.
Julian Schmidt, Anna‐Lena Ziegler, Florian T. Kaps, Laura J. Rosenberger, Matthias Bros, Holger Frey, Robert Luxenhofer   +6 more
wiley   +1 more source

The Skn7 Response Regulator of \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e Interacts with Hsf1 In Vivo and Is Required for the Induction of Heat Shock Genes by Oxidative Stress [PDF]

, 2000
The Skn7 response regulator has previously been shown to play a role in the induction of stress-responsive genes in yeast, e.g., in the induction of the thioredoxin gene in response to hydrogen peroxide.
Erkine, Alexander M., Gross, David S., Johnson, Anthony L., Johnston, Leland H., Makino, Kozo, Morgan, Brian, Raitt, Desmond C.   +6 more
core   +1 more source

A double blind controlled trial comparing three treatment modalities for dentin hypersensitivity [PDF]

, 2011
Aim: This randomized, double blind, split mouth study was aimed to compare three dentin desensitizing treatment modalities. Methods: Two hundred sixty teeth of 25 patients; each having at least 2 hypersensitive teeth in each quadrant, were included ...
Acharya, Aneesha, Bhavsar, Neeta V., Brahmbhatt, Nilam, Kshatriya, Payal, Sahayata, Vishal   +4 more
core   +1 more source

Poly(sarcosine) Lipid Synthesis From CO2‐Based Sarcosine‐N‐Carboxyanhydride

Macromolecular Rapid Communications, EarlyView.
In this work, we optimize and scale‐up a CO2‐based synthesis of sarcosine‐N‐carboxyanhydride (Sar‐NCA) to the gram scale. The low toxicity and simplicity of the approach make it an attractive alternative to current toxic phosgene‐based approaches. The CO2‐based Sar‐NCA has sufficient purity for controlled polymerization.
Florian T. Kaps, Leon Quellmalz, Annika D. S. Richardson, Anna‐Lena Ziegler, Sarah Moreau, Susanne K. Wiedmer, Timo Repo, Robert Luxenhofer   +7 more
wiley   +1 more source