Results 61 to 70 of about 1,125,979 (313)

Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice

Molecular Pain, 2012
Background Oxaliplatin, a platinum-based chemotherapeutic agent, causes an unusual acute peripheral neuropathy. Oxaliplatin-induced acute peripheral neuropathy appears in almost all patients rapidly after infusion, and is triggered or exacerbated by cold,
Zhao Meng, Isami Kouichi, Nakamura Saki, Shirakawa Hisashi, Nakagawa Takayuki, Kaneko Shuji   +5 more
doaj   +1 more source

Wide-Range Measurement of Thermal Preference—A Novel Method for Detecting Analgesics Reducing Thermally-Evoked Pain in Mice

Molecules, 2021
Background: Wide use of oxaliplatin as an antitumor drug is limited by severe neuropathy with pharmacoresistant cold hypersensitivity as the main symptom.
Kinga Sałat, Anna Furgała-Wojas, Michał Awtoniuk, Robert Sałat   +3 more
doaj   +1 more source

Clinical Evaluation of self and professionally applied desensitizing agents in relieving dentin hypersensitivity after a single topical application: a randomized controlled trial [PDF]

, 2014
Objectives: The objective of this study is to evaluate the efficacy of self and professionally applied desensitizing agents in relieving dentinal hypersensitivity after single direct topical application.
Acharya, Shashidhar, Khatri, Sachin-G., Samuel, Srinivasan-Raj   +2 more
core   +2 more sources

Sigma-1 Receptor Inhibition Reduces Neuropathic Pain Induced by Partial Sciatic Nerve Transection in Mice by Opioid-Dependent and -Independent Mechanisms

Frontiers in Pharmacology, 2019
Sigma-1 (σ1) receptor antagonists are promising tools for neuropathic pain treatment, but it is unknown whether σ1 receptor inhibition ameliorates the neuropathic signs induced by nerve transection, in which the pathophysiological mechanisms and response
Inmaculada Bravo-Caparrós, Inmaculada Bravo-Caparrós, Inmaculada Bravo-Caparrós, Gloria Perazzoli, Gloria Perazzoli, Sandra Yeste, Domagoj Cikes, José Manuel Baeyens, José Manuel Baeyens, José Manuel Baeyens, Enrique José Cobos, Enrique José Cobos, Enrique José Cobos, Enrique José Cobos, Francisco Rafael Nieto, Francisco Rafael Nieto, Francisco Rafael Nieto   +16 more
doaj   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Evaluation of aesthetic integration between composite restorations and natural tooth in NCCL: a case report [PDF]

, 2015
NCCL (non carious cervical lesion) is defined as irreversible loss of dental hard tissue that does not involve bacteria. It consists of erosion, attrition, abrasion and abfraction that rarely occur alone.
CORRIDORE, DENISE, GUERRA, Fabrizio, MAZUR , MARTA DANUTA, NARDI, Gianna Maria, OTTOLENGHI, Livia, Pasqualotto, D, Rinaldo, F   +6 more
core  

A Study of Clinical Characteristics of Female Patients with Cold Hypersensitivity on Hands and Feet

Journal of Korean Medicine, 2018
⋅Received:28 May 2018 ⋅Revised:19 June 2018 ⋅Accepted:19 June 2018 ⋅Correspondence to:공경환(Kyung-Hwan Kong) 충북 충주시 상방4길 63 세명대학교 충주한방병원 한방내과학교실 Tel:+82-43-841-1732, Fax:+82-43-856-1731, E-mail:kong124@hanmail.net ⋅Correspondence to:전찬용(Chan-Yong Jeon ...
J. Kwon, Young-ji Kim, K. Kong, C. Jeon, H. Go, Youme Ko   +5 more
semanticscholar   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin

Frontiers in Physiology, 2017
Oxaliplatin, a third-generation platinum-based chemotherapeutic agent, displays unique acute peripheral neuropathy triggered or enhanced by cold, and accumulating evidence suggests that transient receptor potential ankyrin 1 (TRPA1) is responsible. TRPA1
Takahito Miyake, Saki Nakamura, Zhao Meng, Satoshi Hamano, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Kazuki Nagayasu, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko   +11 more
doaj   +1 more source