Results 61 to 70 of about 966,468 (273)

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

The clinicopathologic and immunohistochemical features of 60 cutaneous glomus tumor: a retrospective case series study [PDF]

Anais Brasileiros de Dermatologia
Background Glomus Tumor (GT) are benign neoplasms that originate from mesenchymal cells. It presents as tenderness and cold allodynia in the digits, especially in the subungual region.
Yuehua Sun, Ruiqun Qi, Ze Wu, Xiaodong Zhang, Jun Niu   +4 more
doaj   +1 more source

Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4

BMC Biology, 2020
Background The mechanism underlying the pain symptoms associated with chemotherapeutic-induced peripheral neuropathy (CIPN) is poorly understood. Transient receptor potential ankyrin 1 (TRPA1), TRP vanilloid 4 (TRPV4), TRPV1, and oxidative stress have ...
Francesco De Logu, Gabriela Trevisan, Ilaria Maddalena Marone, Elisabetta Coppi, Diéssica Padilha Dalenogare, Mustafa Titiz, Matilde Marini, Lorenzo Landini, Daniel Souza Monteiro de Araujo, Simone Li Puma, Serena Materazzi, Gaetano De Siena, Pierangelo Geppetti, Romina Nassini   +13 more
doaj   +1 more source

Pain hypersensitivity and spinal nociceptive hypersensitivity in chronic pain: prevalence and associated factors. [PDF]

, 2015
Hypersensitivity of pain pathways is considered a relevant determinant of symptoms in chronic pain patients, but data on its prevalence are very limited. To our knowledge, no data on the prevalence of spinal nociceptive hypersensitivity are available. We
Andersen, Ole Kæseler; id_orcid, Andersen, Ole K, Arendt-Nielsen, Lars, Müller, Monika, Ashraf, Aroosiah, Neziri, Alban Y., Streitberger, Konrad, Curatolo, Michele, Streitberger, Konrad Markus, Müller M, Streitberger K, Ashraf A, Curatolo M, Andersen OK, Neziri AY, Arendt-Nielsen L   +15 more
core   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation. [PDF]

, 2012
Author WILEY ONLINE LIBRARYOxaliplatin-induced peripheral neurotoxicity (OPN) is commonly associated with peripheral hypersensitivity to cold sensations (CS) but the mechanism is unknown.
Manabu Suno, コウノ, トオル, サトミ, マチコ, Hiroyuki Furukawa, Matsubara, Kazuo, 河野, 透, Toru Kono, Kazuo Matsubara, Kono, Toru, Suno, Manabu, Yamazaki, Hirotaka, Hirotaka Yamazaki, 里見, 眞知子, Machiko Satomi, Furukawa, Hiroyuki, Kimura, Norihisa, Norihisa Kimura, Satomi, Machiko   +17 more
core   +1 more source

Integration of the D‐Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability

Advanced Science, EarlyView.
Integration of the D‐genome reshapes gene transcription, chromatin architecture, and the metabolome of hexaploid wheat, leading to enhanced adaptability to salt, UV‐B, and alkali stress. ABSTRACT The hybridization‐led integration of the D‐genome into domesticated tetraploid wheat gave rise to allohexaploid wheat, the most cultivated wheat globally ...
Yanyan Liu, Tao Zhu, Ziru Zhou, Wei Chen, Chao He, Xinkai Zhou, Xin Wang, Chuanye Chen, Bo Yang, Jiaqi Wei, Caixia Lan, Mengmeng Liu, Handong Su, Qiang Li, Xin Hu, Siteng Bi, Weizhi Ouyang, Xingwang Li, Hailiang Mao, Masahiro Kishi, Kerstin Kaufmann, Alisdair R. Fernie, Dijun Chen, Wenhao Yan   +23 more
wiley   +1 more source

Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy.

PLoS ONE, 2011
Paclitaxel (Taxol®) is a widely used chemotherapeutic agent that has a major dose limiting side-effect of painful peripheral neuropathy. Currently there is no effective therapy for the prevention or treatment of chemotherapy-induced painful peripheral ...
Mehmet Fidanboylu, Lisa A Griffiths, Sarah J L Flatters   +2 more
doaj   +1 more source

The prevalence and predictive factors of dentine hypersensitivity among adults in Turkey

BMC Oral Health, 2023
Aim This study sought to determine the prevalence of dentine hypersensitivity (DH) among adults in Turkey. Also, to ascertain the association between DH and both etiological predictors and demographic patient characteristics.
Gunseli Katirci, Esra Uzer Celik
doaj   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source