Results 121 to 130 of about 687 (256)

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

One-step fabrication of superhydrophobic fabrics with stable mechanical performance in harsh conditions. [PDF]

Nat Commun
Liu Z, Zhao K, Ma J, Liu S, Zhan Z, Yu C, Wu L, Hao D, Jiang L, Dong Z.   +9 more
europepmc   +1 more source

A Flow Stress Model of the AA3104-H19 Alloy for the FEM Simulation of the Beverage Can Manufacturing Process under Large Plastic Deformations. [PDF]

Materials (Basel), 2021
Wędrychowicz P, Kustra P, Paćko M, Milenin A.   +3 more
europepmc   +1 more source

Ultrasound‐Activated Ce(IV)‐Integrated Biomimetic Nanoplatform for Oxygenation‐Reinforced Gas‐Sonodynamic Ferroptosis and cGAS–STING‐Driven Antitumor Immunity

Advanced Science, EarlyView.
A Ce(IV)‐integrated biomimetic nanoplatform coordinates tumor oxygenation, ultrasound‐triggered carbon monoxide release, sonodynamic therapy, ferroptosis amplification, and cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) immune activation.
Mengli Ma, Yingying Wu, Yunjie Wang, Yang Li, Yijia Zhang, Zhibo Zhang, Jinzhi Peng, Xiangyu Wu, Yi Luo, Weijing Zhang, Xin Ye, Weisong Lai, Shengyu Wang, Dan Du, Wengang Li, Nan Zheng, Fanghong Luo, Ting Wu   +17 more
wiley   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Hybrid Lasso-random forest framework for energy prediction using wireless sensor networks in low-energy buildings. [PDF]

Sci Rep
Li G, Luo Y, Luo Z, Bennett NS, Islam MS.   +4 more
europepmc   +1 more source

Magnetic Thermal Ablation Combined with Temporally Coordinated CpG Immunotherapy Promotes cDC1‐Dependent Immune Priming in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Novel PLA@Fe3O4 magnetic microspheres were developed for transarterial magnetic hyperthermia ablation (MTA) of hepatocellular carcinoma. While destroying local tumors and inducing immunogenic cell death (ICD), MTA combined with early CpG adjuvant administration significantly promotes cDC1‐dependent immune priming. This synergistic mechanism effectively
Jiakun Yang, Nailin Yang, Shuangshuang Ji, Siping Meng, Di Wang, Wenjun Liang, Xuming Bai, Yong Jin, Xingwei Sun   +8 more
wiley   +1 more source

Treatment of abdominal pain due to deficiency syndrome of the spleen and stomach with Bian stone plus TCM iontophoresis: A case report. [PDF]

Medicine (Baltimore)
Guo HL, Zhao J, Feng WY, Tian XD, Huang YP.   +4 more
europepmc   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Application of traditional Chinese medicine nursing technology: Traditional Chinese medicine ironing combined with traditional Chinese medicine massage in improving functional constipation in elderly patients. [PDF]

Medicine (Baltimore)
Tan L, Qin W, Liao J, Liu Y, Yan L.
europepmc   +1 more source