Results 181 to 190 of about 27,811 (300)

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

'Remember, You Are Not Alone': A Qualitative Internet-Mediated Study of Anxiety Among Adolescents on Reddit. [PDF]

Int J Ment Health Nurs
Kaluzeviciute G, Moreton JPI, Jackson JE.   +2 more
europepmc   +1 more source

Government Efforts to Aid Consumer Well-being: Understanding Federal Health Warnings and Disclosures [PDF]

, 2015
Andrews, J. Craig, Burton, Scot, Kees, Jeremy   +2 more
core   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

A qualitative interview study exploring the lived experiences of adults, adolescents, and children with chronic inducible cold urticaria. [PDF]

J Patient Rep Outcomes
Alladin A, Guillemin I, Chuang CC, Chao J, Krol M, Zikos E, Martincova R, Brookes E.   +7 more
europepmc   +1 more source

Development of Cold (Bi-Spectral) Neutron Moderators for the IBR-2 Reactor. Current Status and Plans [PDF]

, 2018
S. Kulikov, Vladimir Ananiev, A. A. Belyakov, M. V. Bulavin, К. А. Мухин, Anatoly A. Rogov, E. P. Shabalin, A. E. Verkhoglyadov   +7 more
openalex   +1 more source

Cold moderator options for a Hi-CANS

, 2022
openaire   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Intergenerational stability in parenting across two generations: A multilevel meta-analytic review. [PDF]

Psychol Bull
Geeraerts SB, Spitzer J, Schulz S, Capaldi DM, Kerr DCR, Branje S.   +5 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source