Results 181 to 190 of about 714,917 (255)

The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism. [PDF]

Mol Metab
Evangelakos I, Verkade E, Rohde JK, Zaufel A, Vargek M, Heine M, Worthmann A, Graute S, Manka Fuh M, Gunasekaran K, Kumari M, Schwinge D, von Bergen M, Rolle-Kampczyk U, Engelmann B, Breinbauer R, Fuerst R, Saleem U, de Boer JF, Schlein C, Hansen A, Scheja L, Kuipers F, Moustafa T, Heeren J.   +24 more
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Cold Shock for Cold Tolerance: Phytohormone Dynamics in Sorghum Provides Insights. [PDF]

Plant Direct
Neitzert L, Kravcov N, Moya YAT, Windpassinger S, von Wirén N, Snowdon R, Wittkop B.   +6 more
europepmc   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Genome-wide association mapping and candidate genes analysis of high-throughput image descriptors for wheat frost tolerance. [PDF]

Stress Biol
Yu R, Liu Y, Yuan M, Jiang P, Zhao J, Zhang C, Xu X, Wang Q, Wang Y, Chen T, Ou J, Luo Y, Dong H, Kang Z, Zeng Q, Zhao Y, Liu S, Su B, Han D, Wu J.   +19 more
europepmc   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

A Whole-body Cooling Strategy in Uncontrolled Donation After Circulatory Death: Insights From a Porcine Ex Vivo Lung Perfusion Model. [PDF]

Transplant Direct
Niikawa H, Sakota D, Kosaka R, Sakanoue I, Baba S, Ohuchi K, Kigata T, Farver CF, McCurry KR, Okada Y, Okamoto T.   +10 more
europepmc   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Convective storms alter bioaerosol populations through cold pools and precipitation.

Environ Sci Atmos
Feldman TK, Mampage CBA, Falk NM, Fernando JC, Heffernan B, Hill TCJ, Juergensen D, Mignani C, Nieto-Caballero M, Grant LD, van den Heever SC, DeMott PJ, Kreidenweis SM, Perkins RJ, Stone EA.   +14 more
europepmc   +1 more source

SARS-CoV-2 vaccines induce a diverse spike-specific CD4+ T cell receptor repertoire in people living with HIV with low CD4 nadirs. [PDF]

Front Immunol
Mercado A, Sop J, Amanat S, Zhang L, Chida NM, Basseth CR, Gebo KA, Antar AAR, Smith KN, Zeng Z, Blankson JN.   +10 more
europepmc   +1 more source