Results 241 to 250 of about 162,200 (291)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism. [PDF]

Mol Metab
Evangelakos I, Verkade E, Rohde JK, Zaufel A, Vargek M, Heine M, Worthmann A, Graute S, Manka Fuh M, Gunasekaran K, Kumari M, Schwinge D, von Bergen M, Rolle-Kampczyk U, Engelmann B, Breinbauer R, Fuerst R, Saleem U, de Boer JF, Schlein C, Hansen A, Scheja L, Kuipers F, Moustafa T, Heeren J.   +24 more
europepmc   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

A Comprehensive Review of Strategies to Advance Kidney Exchange Programs and Optimize Effectiveness and Outcomes. [PDF]

Kidney Int Rep
van de Laar SC, de Heus HA, de Weerd AE, Klaassen MF, Porte RJ, Minnee RC, Dor FJMF.   +6 more
europepmc   +1 more source

Heterojunction‐Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases

Advanced Science, EarlyView.
Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen, Chaoqi Wang, Xi Yu, Yuming Jiang, Yijiao Qu, Huihui Fu, Yuyin Bu, Xiaoyong Zhang, Zongxiu Nie   +8 more
wiley   +1 more source

Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation. [PDF]

Nucleic Acids Res
Fang D, Babich JM, Stanton R, Vock IW, Abdallah K, Zhu M, Letchuman R, Li R, Simon MD, Gilbert WV, Nachtergaele S.   +10 more
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Cold Shock for Cold Tolerance: Phytohormone Dynamics in Sorghum Provides Insights. [PDF]

Plant Direct
Neitzert L, Kravcov N, Moya YAT, Windpassinger S, von Wirén N, Snowdon R, Wittkop B.   +6 more
europepmc   +1 more source

Genome-wide association mapping and candidate genes analysis of high-throughput image descriptors for wheat frost tolerance. [PDF]

Stress Biol
Yu R, Liu Y, Yuan M, Jiang P, Zhao J, Zhang C, Xu X, Wang Q, Wang Y, Chen T, Ou J, Luo Y, Dong H, Kang Z, Zeng Q, Zhao Y, Liu S, Su B, Han D, Wu J.   +19 more
europepmc   +1 more source

SARS-CoV-2 vaccines induce a diverse spike-specific CD4+ T cell receptor repertoire in people living with HIV with low CD4 nadirs. [PDF]

Front Immunol
Mercado A, Sop J, Amanat S, Zhang L, Chida NM, Basseth CR, Gebo KA, Antar AAR, Smith KN, Zeng Z, Blankson JN.   +10 more
europepmc   +1 more source