Results 31 to 40 of about 1,190,556 (287)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Ecotoxicology and Environmental SafetyThe Fe3O4 nanoparticle synthesized by Acidithiobacillus ferrooxidans have a broad practical value, while the low yield limits their commercial application. Herein, we employed a 12C6+ heavy-ion beam to induce mutagenesis of A.
Jiani Yang +6 more
doaj +1 more source
Stiffness Characterization of Cold Recycled Mixtures
Transportation Research Procedia, 2016 AbstractOne of the objectives within the European research project CoRePaSol (supported within the CEDR Transnational Program) was to summarize assessment and research of stiffness modulus of cold recycled mixes determined according to repeated indirect tensile stress test (IT-CY).
Valentin, J. +5 more
openaire +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Structural Contribution of Cold In-Place Recycling Base Layer
CivilEng, 2021 Cold in-place recycling (CIR) of asphalt pavements is a process that has successfully been used for many years. The use of CIR for rehabilitation offers many advantages over traditional overlays due to its excellent resistance to reflective cracking and ...
Mateo E. Carvajal +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Durability of recycled aggregate concrete in cold regions
Case Studies in Construction Materials, 2022 The combination of experimental programs and finite element numerical methods is adopted to explore the durability of WBC (waste brick concrete). Rapid freeze-thaw and flexural tests are performed with the content of WBCA (waste brick coarse aggregate) and the number of freeze-thaw cycles as variables.
Yongcheng Ji, Dayang Wang
openaire +2 more sources
Filler Effect on Moisture Resistance of Cold Recycling Materials
, 2022 Cold recycling materials (CRM) with bitumen emulsion are getting increasingly important, aiming at highly efficient road infrastructure and tackling energy consumption, as well as its further consequences on climate change [...
Ahmed Al-Mohammedawi, Konrad Mollenhauer
core +1 more source
FEBS Open Bio, EarlyView.The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao +23 more
wiley +1 more source