Results 91 to 100 of about 5,221,850 (348)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Improvements of the Variable Thermal Resistance [PDF]

, 2007
A flat mounting unit with electronically variable thermal resistance [1] has been presented in the last year [2]. The design was based on a Peltier cell and the appropriate control electronics and software. The device is devoted especially to the thermal
Kollar, E., Szekely, V., Torok, S.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Laboratory and Rig Tests of High-Strength and High Crack Resistance Wheel Tyres

Вестник Научно-исследовательского института железнодорожного транспорта, 2015
The paper presents development/comprehension tests outcomes of locomotive wheel tyre prototypes of grade ‘H’ medium alloy steel. These high-strength and high crack resistance tyres are intended for use with series 2EC10, 2EC7 and 2EC6 new generation ...
G. I. Bryunchukov, A. S. Razumov, A. V. Sukhov, A. V. Zorin, R. A. Il’Inykh, V. V. Brekson   +5 more
doaj  

Electrical resistance determination of actual contact area of cold welded metal joints [PDF]

, 1970
Method measures the area of the bonded zone of a compression weld by observing the electrical resistance of the weld zone while the load changes from full compression until the joint ruptures under tension.
Hordon, M. J.
core   +1 more source

Strong enhancement of Jc in binary and alloyed in-situ MgB2 wires by a new approach: Cold high pressure densification

, 2009
Cold high pressure densification (CHPD) is presented as a new way to substantially enhance the critical current density of in situ MgB2 wires at 4.2 and 20 K at fields between 5 and 14 T.
C Senatore, Collings E W, Eisterer M, Flükiger R Hossain M S A Senatore C, Flükiger R Senatore C Hossain M S A Zhang X Wang D Ma Y W, Hossain M S A, Hossain M S A, Lezza P, M S A Hossain, Ma Y W, Pan A V, Prikhna T A, R Flukiger, Rowell J M, Yamada H, Yamamoto A, Zhang X P   +16 more
core   +2 more sources

Analysis of cold resistance and identification of SSR markers linked to cold resistance genes in Brassica rapa L.

Breeding Science, 2017
Currently, cold temperatures are one of the main factors threatening rapeseed production worldwide; thus, it is imperative to identify cold-resistant germplasm and to cultivate cold-resistant rapeseed varieties. In this study, the cold resistance of four
Zhen Huang, Xuexian Zhang, Shouhua Jiang, Mengfan Qin, Na Zhao, Lina Lang, Yaping Liu, Zhengshu Tian, Xia Liu, Yang Wang, Binbin Zhang, Aixia Xu   +11 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Redefining awn development in rice through the breeding history of Japanese awn reduction

Frontiers in Plant Science
The study challenges the conventional understanding of awn loss as a domestication syndrome, showing instead that many awned varieties continued to be widely grown in Japan until the early twentieth century and that selection for awn reduction was active
Mao Suganami, Hideki Yoshida, Shinya Yoshida, Shinya Yoshida, Mayuko Kawamura, Eriko Koketsu, Makoto Matsuoka, Soichi Kojima   +7 more
doaj   +1 more source

A chromosome‐scale reference genome of trifoliate orange (Poncirus trifoliata) provides insights into disease resistance, cold tolerance and genome evolution in Citrus

The Plant Journal, 2020
SUMMARY Trifoliate orange (Poncirus trifoliata), a deciduous close relative of evergreen Citrus, has important traits for citrus production, including tolerance/resistance to citrus greening disease (Huanglongbing, HLB) and other major diseases, and cold
Ze Peng, Jessen V. Bredeson, G. Wu, S. Shu, Nidhi Rawat, Dongliang Du, Saroj Parajuli, Qibin Yu, Qian You, D. Rokhsar, F. Gmitter, Z. Deng   +11 more
semanticscholar   +1 more source