Results 121 to 130 of about 1,450,504 (279)

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Deuterium retention in cold spray tantalum coatings vs. polycrystalline tungsten and tantalum

Nuclear Fusion
Enhanced deuterium retention in tantalum (Ta) cold spray coatings, compared to reference polycrystalline tantalum and tungsten materials, has been evaluated using the thermal desorption spectrometry technique.
Mykola Ialovega, Marcos Xavier Navarro-Gonzalez, Régis Bisson, Jay Anderson, Thierry Angot, Tyler Dabney, Cary Forest, Arkadi Kreter, Danah Velez, Evan Willing, Hwasung Yeom, Kumar Sridharan, Oliver Schmitz   +12 more
doaj   +1 more source

Cold spraying superalloys：research status，challenges and perspectives

Cailiao gongcheng
Cold spraying technology has a number of unique characteristics， most notably the solid-state metal powder deposition. This property confers the technology with significant technical advantages and application potentials in the domains of coating ...
LI Wenya, WU Gefei, LI Yuhan, XU Yaxin, HUANG Chunjie, LUO Xiaotao, XIE Yingchun, YIN Shuo   +7 more
doaj   +1 more source

Recent advances on bonding mechanism in cold spray process: A review of single-particle impact methods. [PDF]

J Mater Res, 2023
Adaan-Nyiak MA, Tiamiyu AA.
europepmc   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Evaluation of the Fatigue Behavior and Failure Mechanisms of 4340 Steel Coated with WIP-C1 (Ni/CrC) by Cold Spray. [PDF]

Materials (Basel), 2022
Goanță V, Munteanu C, Müftü S, Istrate B, Schwartz P, Boese S, Ferguson G, Morăraș CI, Stefan A.   +8 more
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

A Repair Method for Damage in Aluminum Alloy Structures with the Cold Spray Process. [PDF]

Materials (Basel), 2021
Han X, Sun X, Li G, Huang S, Zhu P, Shi C, Zhang T.   +6 more
europepmc   +1 more source

ERAD Component MoHrd3 Facilitates Pathogenicity and Establishes a Direct Regulation on Autophagy in Magnaporthe Oryzae

Advanced Science, EarlyView.
MoHrd3 plays a crucial role in regulating the pathogenicity of Magnaporthe oryzae. As an ER‐associated degradation component, MoHrd3 involves in ER stress‐triggered autophagy. It facilitates the fusion between the autophagosome and the vacuole via enhancing the interaction between MoAtg8 and MoYpt7.
Huiqing Xia, Yunna Zheng, Nan Yang, Jing Chen, Xi Wu, Ximing Zheng, Danrui Cui, Ruijin Wang, Xunli Lu, Dongli Wang, You‐liang Peng, Qian Chen   +11 more
wiley   +1 more source

On the Importance of Secondary Component Properties for Cold Spray Metallization of Carbon Fiber Reinforced Polymers. [PDF]

J Therm Spray Technol, 2022
Liberati AC, Che H, Aghasibeig M, Yu KR, Vo P, Yue S.   +5 more
europepmc   +1 more source