Results 91 to 100 of about 17,986 (306)

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Highlighting Recent Progress in Fiber Energy Harvesters: From Working Principles to Future Perspectives

Advanced Science, EarlyView.
Fiber energy harvesters offer unprecedented flexibility and a unique capacity for integration into commercial textiles, overcoming the limitations of bulky and rigid conventional devices. This review summarizes recent advances in fiber‐based energy harvesting and provides strategic outlooks to accelerate technological progress in the field. ABSTRACT As
Hanhwi Jang, Junseong Ahn, Yongrok Jeong, Sohee Jeon, Soon Hyoung Hwang, Min‐Wook Oh, Jun‐Ho Jeong, Inkyu Park, Yeon Sik Jung   +8 more
wiley   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Fabrication of Functionally Graded Material (FGM) Set-Up [PDF]

, 2015
Functionally graded materials (FGMs) are advanced composites with graded properties that are novel concepts in the structural design of materials and have extensive applications in the aerospace engineering, aircrafts and automotive industry.
Sahoo, Deepak Kumar
core  

Surface topography analysis in cold spray additive manufacturing

Precision Engineering
Additive manufacturing, and particularly the cold spray technology for additive manufacturing (CSAM), is fast becoming a key technology to produce components in an efficient and environmentally friendly manner. This method usually requires a final rectification to generate specific surface topographies.
Paloma Sirvent, Ana Lozano, Miguel A. Garrido-Maneiro, Pedro Poza, Rordolpho F. Vaz, Vicente Albaladejo-Fuentes, Irene G. Cano   +6 more
openaire   +3 more sources

Cold spraying superalloys：research status，challenges and perspectives

Cailiao gongcheng
Cold spraying technology has a number of unique characteristics， most notably the solid-state metal powder deposition. This property confers the technology with significant technical advantages and application potentials in the domains of coating ...
LI Wenya, WU Gefei, LI Yuhan, XU Yaxin, HUANG Chunjie, LUO Xiaotao, XIE Yingchun, YIN Shuo   +7 more
doaj   +1 more source

Solid-State Cold Spray Additive Manufacturing of Ni-Based Superalloys: Processing-Microstructure-Property Relationships. [PDF]

Materials (Basel), 2023
Ralls AM, Daroonparvar M, John M, Sikdar S, Menezes PL.   +4 more
europepmc   +1 more source

Cold spray - a solid-state additive manufacturing technology

IOP Conference Series: Materials Science and Engineering
Abstract Cold spray is a solid-state powder deposition technique and has evolved into an additive manufacturing process. Unlike conventional additive manufacturing technologies that rely on melting and solidification, cold spray additive manufacturing (CSAM) forms components at low temperatures at a relatively high build rate.
Congcong Su, Yan Wang, Hanqing Che, Stephen Yue, Xiaoxu Huang   +4 more
openaire   +1 more source