Results 91 to 100 of about 1,863 (256)

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Pack aluminizing by induction heating: application to Inconel 718 produced by cold spray additive manufacturing

Materials Research Express
This study investigates the formation of aluminide coatings on Inconel 718 (IN718) superalloy produced by Cold Spray Additive Manufacturing (CSAM) using Pack Induction Aluminizing (PIA) process.
Aptullah Karakaş, Erdem Balcı, Murat Baydoğan   +2 more
doaj   +1 more source

A Machine Learning Approach for Predicting Particle Spatial, Velocity, and Temperature Distributions in Cold Spray Additive Manufacturing

Applied Sciences
Masked cold spray additive manufacturing (CSAM) is investigated for fabricating nickel-based electrodes with pyramidal pin-fins that enlarge the active area for the hydrogen-evolution reaction (HER).
Lurui Wang, Mehdi Jadidi, Ali Dolatabadi
doaj   +1 more source

Cold spray - a solid-state additive manufacturing technology

IOP Conference Series: Materials Science and Engineering
Abstract Cold spray is a solid-state powder deposition technique and has evolved into an additive manufacturing process. Unlike conventional additive manufacturing technologies that rely on melting and solidification, cold spray additive manufacturing (CSAM) forms components at low temperatures at a relatively high build rate.
Congcong Su, Yan Wang, Hanqing Che, Stephen Yue, Xiaoxu Huang   +4 more
openaire   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Multi-particle impact behavior of Cu nanoparticles: A molecular dynamics investigation

Next Materials
While the single-particle impact model is widely used in studying the high-velocity impact behavior of particles, its scope is limited to the interaction between an individual particle and the substrate.
Che Zhang, Zhou Li, Jiaqing Li, Peng Gao, Rui Wang, Chunyang Xia, Guanyu Deng   +6 more
doaj   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy

BMEMat, EarlyView.
Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim, Hak Yong Kim, Ja Hoon Koo, Gi Doo Cha, Dae‐Hyeong Kim, Hye Jin Kim   +5 more
wiley   +1 more source

Paradigm shift in wearable bioelectronics: Drift‐free organic field‐effect transistor biosensors enabled by diode‐connected pairs

BMEMat, EarlyView.
Organic field‐effect transistor (OFET)‐based biosensors are promising for wearable technology due to their flexibility and low cost, but their susceptibility to signal drift from mechanical stress and environmental factors remains a challenge. Here, we highlight a novel strategy that eliminates these drifts through a fundamental redesign of the OFET ...
Yan Xu, Bin Yao, Jiahe Wang, Yichun Ding
wiley   +1 more source