Results 151 to 160 of about 17,379 (304)

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Cold gas dynamic spraying of titanium coatings [PDF]

, 2008
Cold gas dynamic spraying, CGDS, is a relatively new technique used to deposit materials onto the surface of a substrate. It differs to the majority of other thermal spray techniques as the substrate and particles are not exposed to high temperatures ...
Price, Timothy Simon
core  

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy

BMEMat, EarlyView.
Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim, Hak Yong Kim, Ja Hoon Koo, Gi Doo Cha, Dae‐Hyeong Kim, Hye Jin Kim   +5 more
wiley   +1 more source

Paradigm shift in wearable bioelectronics: Drift‐free organic field‐effect transistor biosensors enabled by diode‐connected pairs

BMEMat, EarlyView.
Organic field‐effect transistor (OFET)‐based biosensors are promising for wearable technology due to their flexibility and low cost, but their susceptibility to signal drift from mechanical stress and environmental factors remains a challenge. Here, we highlight a novel strategy that eliminates these drifts through a fundamental redesign of the OFET ...
Yan Xu, Bin Yao, Jiahe Wang, Yichun Ding
wiley   +1 more source

H2O2 Activation and Alkane Oxidation by Copper Complexes With R‐dpa N3‐Tridentate Ligands: The Complex‐Based Dicopper Active Species as a Key Feature in the Efficient Alkane Oxidation

Chemistry – A European Journal, EarlyView.
Two reaction pathways, Paths 1 and 2, are involved in H2O2 activation by Cu complexes with N3‐tridentate ligands, depending on the ease of bridging structure formation. In Path 1, hydroxy radical (HO•) is formed from a hydroperoxo Cu(II) intermediate. In Path 2, a relevant complex‐based μ‐O• bridged Cu(II)2 active species is formed from a bis‐μ‐oxo Cu ...
Kyosuke Fujikawa, Momoe Kawahashi, Alexander Granichny, Siegfried Schindler, Hiroaki Kitagishi, Masahito Kodera   +5 more
wiley   +1 more source

Development of a Mechanically Regenerating Desublimator for Freeze‐Drying Systems in the Food Industry

Chemie Ingenieur Technik, EarlyView.
Thermal defrosting limits desublimator efficiency in freeze‐drying. This review and case study compares thermal versus mechanical regeneration, links frost properties and external heat transfer to energy demand, and summarizes pilot‐scale scraping results enabling single‐unit, continuous lyophilization.
Moritz Krummenacher, Mirko Kleingries, Edgar Zimmer, Roman Blättler   +3 more
wiley   +1 more source

Exploring Tradeoffs in Syngas Production With Solid‐Oxide Electrolysis via Multi‐Objective Optimization

Chemie Ingenieur Technik, EarlyView.
This work applies multi‐objective optimization to investigate trade‐offs between different objectives in syngas production with solid‐oxide cell co‐electrolysis. Two system designs are investigated. By systematically exploring tradeoffs between different objectives, insights, and comparisons of the operation of these designs are achieved.
Gbenga Jerome, Victor Selmert, An Phuc Dam, Nicolas Kruse, Leandros Paschalidis, Remzi Can Samsun, Rüdiger‐A. Eichel   +6 more
wiley   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source