Results 61 to 70 of about 1,807,508 (248)

Recommendations from Cold Starts in Big Data [PDF]

Proceedings of the 4th International Conference on Internet of Things, Big Data and Security, 2019
AbstractThis paper examines the challenging problem of new user cold starts in subset labelled and extremely sparsely labelled big data. We introduce a new Isle of Wight Supply Chain (IWSC) dataset demonstrating these characteristics. We also introduce a new technique addressing these challenges, the Transitive Semantic Relationships (TSR) model, which
David Ralph, Yunjia Li, Gary B. Wills, Nicolas G. Green   +3 more
openaire   +3 more sources

Exploiting Past Users’ Interests and Predictions in an Active Learning Method for Dealing with Cold Start in Recommender Systems

, 2018
This paper focuses on the new users cold-start issue in the context of recommender systems. New users who do not receive pertinent recommendations may abandon the system. In order to cope with this issue, we use active learning techniques.
Meziane, F.
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Cold Start Strategy of the CubeSat GPS Receiver

Advances in Electrical and Computer Engineering, 2014
The cold start of the LEO satellite GPS receiver is complicated due to a large Doppler frequency shift, Doppler frequency rate of the navigation signals and a rapid change of the satellite visibility.
KOVAR, P., JELEN, S.
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

COCOA: cold start aware capacity planning for function-as-a-service platforms [PDF]

, 2020
Function-as-a-Service (FaaS) is increasingly popularin the software industry due to the implied cost-savings in event-driven workloads and its synergy with DevOps.
Gias, Alim, Gias, A., Casale, Giuliano, Casale, G., Giuliano Casale, Gias, Alim Ul, Alim Ul Gias, Gias, A.U.   +7 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Optimization of fuel cell-assisted heating cold-start strategy based on NSGA-II algorithm

Química Nova
The cold start of fuel cells presents a major bottleneck in commercialization, with auxiliary heating strategies serving as a crucial method to achieve rapid cold start.
Yongming Shao, Mingyu Lu, Haomai Feng, Yucheng Hou, Yueqi Si   +4 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source