Results 121 to 130 of about 1,678,742 (220)

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

open access: yesAdvanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng   +7 more
wiley   +1 more source

[Report] Bethlehem Steel Company : employees of Bethlehem Steel Company : with their salaries and wages

open access: yes, 1901
This is a report of the employees of the Bethlehem Steel Company, along with wages and salaries from 1901. The report provides statistical data about the employees at the Bethlehem Steel, specifically detailing the number of workers employed per "class ...

core  

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

open access: yesAnimal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu   +3 more
wiley   +1 more source

Chrysin attenuates diabetes‐induced retinal injury by inhibiting microglial GBP3/NLRP3/GSDMD‐mediated pyroptosis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We investigated the therapeutic potential and mechanism of chrysin in experimental diabetic retinal disease. Using a streptozotocin (STZ)‐induced diabetic mouse model and high‐glucose‐stimulated BV2 microglia, we revealed chrysin‐responsive pyroptosis‐associated signatures and identified GBP3 as a regulated node.
Qun Liu   +9 more
wiley   +1 more source

BiZact versus cold steel for post-tonsillectomy hemorrhage: a multicenter randomized trial. [PDF]

open access: yesEur Arch Otorhinolaryngol
Mølhave M   +7 more
europepmc   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

open access: yesCytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham   +3 more
wiley   +1 more source

Development and validation of a machine learning model predicting post-tonsillectomy hemorrhage. [PDF]

open access: yesEur Arch Otorhinolaryngol
Stubberud A   +3 more
europepmc   +1 more source

Biaxial bending of cold-formed steel storage rack uprights - Part I: FEA and parametric studies

open access: yes, 2018
This paper first introduces an advanced finite element model to determine the biaxial bending capacity of cold-formed steel storage rack upright sections.
Gilbert, BP   +4 more
core  

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