Results 161 to 170 of about 182,891 (332)

Characterizing, modelling and understanding the climate variability of the deep water formation in the North-Western Mediterranean Sea [PDF]

open access: yes, 2016
Observing, modelling and understanding the climate-scale variability of the deep water formation (DWF) in the North-Western Mediterranean Sea remains today very challenging.
A Bosse   +106 more
core   +3 more sources

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

open access: yesCancer Communications, EarlyView.
Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grade serous ovarian cancer (HGSOC), but the underlying ...
Chenyang Wang   +11 more
wiley   +1 more source

Meltwater Intrusions Reveal Mechanisms for Rapid Submarine Melt at a Tidewater Glacier [PDF]

open access: yes, 2019
Submarine melting has been implicated as a driver of glacier retreat and sea level rise, but to date melting has been difficult to observe and quantify. As a result, melt rates have been estimated from parameterizations that are largely unconstrained by ...
Amundson, Jason M.   +8 more
core   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

open access: yesCancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu   +12 more
wiley   +1 more source

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

open access: yesCancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao   +12 more
wiley   +1 more source

Effect of Thermal Period on Seed Dormancy of Damask Rose (Rosa damascena Mill.) [PDF]

open access: yesJournal of Medicinal Plants and By-products, 2012
Damask rose (Rosa damascena Mill.) has high economic importance and commercial value. The plant essential oil is used for perfumery, food and medicinal industries.
doaj  

Radiative and dynamic stability of a dilute plasma [PDF]

open access: yesarXiv, 2010
We analyze the linear stability of a dilute, hot plasma, taking into account the effects of stratification and anisotropic thermal conduction. The work is motivated by attempts to understand the dynamics of the intracluster medium in galaxy clusters.
arxiv  

The Role of Personality Traits and Entrepreneurial Self‐Efficacy in SME Sustainability

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the role of personality traits in shaping sustainable business practices among entrepreneurs, focusing on the mediating role of entrepreneurial self‐efficacy. Grounded in Social Cognitive Theory, we conceptualize entrepreneurial self‐efficacy as a cognitive belief mechanism that strengthens entrepreneurs' confidence in ...
Saša Malenković, Alenka Slavec Gomezel
wiley   +1 more source

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