Results 81 to 90 of about 40,088 (283)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

The Study of Seed Germination and Dormancy of Chenopodium album, Convolvulus arvensis and Setaria viridis in Pistachio Orchards of Rafsanjan, Iran

پژوهش‌های بذر ایران, 2017
In order to study the seed germination behavior and dormancy breaking methods of three weed species (i.e., Chenopodium album, Convolvulus arvensis and Setariaviridis) of pistachio orchards in Rafsanjan, Iran, three separate factorial experiments (with 2 ...
Mostafa Alinaghizadeh, Mohammad Khajeh-Hosseini, Seyed Ahmad Hosseini, Mohammad Hasan Rashed Mohasel   +3 more
doaj  

Seed dormancy types and germination response of 15 plant species in temperate montane peatlands

Ecology and Evolution
Despite their crucial role in determining the fate of seeds, the type and breaking mode of seed dormancy in peatland plants in temperate Asia with a continental monsoon climate are rarely known.
Jian‐Yi Wang, Zhao‐Jun Bu, Peter Poschlod, Shuayib Yusup, Jia‐Qi Zhang, Zheng‐Xiang Zhang   +5 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Effects of TiO2 Nanoparticles on Germination and Primary Growth of Mountain Ash (Sorbus luristanica)

پژوهش‌های بذر ایران, 2019
DOR: 98.1000/2383-1251.1398.6.173.11.1.1575.41 Extended Abstract Introduction: Production of nanoparticles and their use are on the rise in different areas of plant science. However, in spite of their increasing production, there is limited information
Vahid Sayedena, Babak Pilehvar, Kambiz Abrari-Vajari, Mehrdad Zarafshar, Hamid Reza Eisvand   +4 more
doaj  

Seed Dormancy Class and Germination Characteristics of Berberis amurensis var. latifolia Nakai, Native to Korea

Agronomy
Berberis amurensis var. latifolia Nakai is a plant native to the Ulleung Island in Korea. In this study, we aimed to identify seed dormancy-breaking and germination requirements of this species using water imbibition experiments, gibberellic acid (GA3 ...
Do-Hyun Kim, Da-Hyun Lee, Ji-Yoon Park, Hyeon-Min Kim, Jun-Hyeok Kim, Hoi-Jin Kim, Sang-Hoon Che, Chae-Sun Na, Do-Hyung Lee   +8 more
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Germination and Dormancy in Annual Halophyte Juncus ranarius Song & Perr.

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2015
The effects of cold stratification and gibberellic acid (GA3) on dormancy breaking for seeds of the annual halophyte species Juncus ranarius were tested. Germination percentage and recovery responses of salt stressed seeds were also tested.
Jeremi KOŁODZIEJEK, Jacek PATYKOWSKI
doaj   +1 more source