Results 61 to 70 of about 2,406,274 (307)

COLD-WATER TREATMENT OF FEVERS [PDF]

The Lancet, 1871
n ...
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Chromosome-level genome assembly and population genomic analysis provide insights into the genetic diversity and adaptation of Brachymystax lenok tsinlingensis in China

Genomics Communications
Brachymystax lenok tsinlingensis, a cold-water fish endemic to China, has undergone a severe population decline because of habitat fragmentation and overfishing. We generated a high-quality 2.03 Gb reference genome of B. lenok tsinlingensis, a freshwater
Changping Jiang, Yanyan Du, Yanping Zhang, Tai Wang   +3 more
doaj   +1 more source

Genomic selection models substantially improve the accuracy of genetic merit predictions for fillet yield and body weight in rainbow trout using a multi-trait model and multi-generation progeny testing

Genetics Selection Evolution, 2023
Background In aquaculture, the proportion of edible meat (FY = fillet yield) is of major economic importance, and breeding animals of superior genetic merit for this trait can improve efficiency and profitability. Achieving genetic gains for fillet yield
Andre Garcia, Shogo Tsuruta, Guangtu Gao, Yniv Palti, Daniela Lourenco, Tim Leeds   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Why the lipid deposition in the muscle fibers and myosepta is selective in triploid rainbow trout? A lncRNA‒mRNA study

BMC Genomics
Salmonids can accumulate lipids in their fillets, creating marbled features with alternate red (Muscle Fibers, MF) and white stripes (Myosepta, MS). To investigate the regulation of this important quality trait, diets with low and high lipid levels were ...
Qianwen Li, Falie Shi, Guoliang Sun, Fulei Wei, Zezhong Wu, Rui Ma, Yuqiong Meng   +6 more
doaj   +1 more source

Effects of nano-TiC and nano-CaCO3 on steel fiber-reinforced cementitious mortar: a study on mechanical properties and freeze-thaw performance

Frontiers in Materials
Steel fiber (SF) cement mortar, renowned for its dual advantages of strength and toughness, is widely used in construction, transportation, and other engineering fields.
Tian Bai, Xin Yang, Zhengjun Wang, Kai Chen   +3 more
doaj   +1 more source

Cyclonic cold-core eddy in the eastern North Atlantic. II. Nutients, phytoplankton and bacteriaplankton [PDF]

, 1987
A cyclonic cold-core eddy in the Northeast Atlantic of about 100 km in diameter at the sea surface was investigated in May 1985, approximately 3 wk after it had separated from the Polar Front.
Lochte, Karin, Pfannkuche, Olaf
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Development and application of an updated haplotype reference panel for association analysis of spontaneous sex reversal in XX rainbow trout

Frontiers in Genetics
With the rapid cost reduction of next-generation sequencing, low-coverage whole-genome sequencing (lcWGS) followed by genotype imputation is becoming a cost-effective alternative to SNP (single nucleotide polymorphism) array genotyping.
Sixin Liu, Gregory M. Weber, Kyle E. Martin, Roseanna Long, Jill E. Birkett, Yniv Palti   +5 more
doaj   +1 more source