Results 71 to 80 of about 2,406,274 (307)
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Consequences of ocean scale hypoxia constrained habitat for tropical pelagic fishes [PDF]
, 2007 Large areas of cold hypoxic water occur as distinct strata in the eastern tropical Pacific and Atlantic oceans as a result of high productivity initiated by intense nutrient upwelling.
Goodyear, C.P., Prince, Eric D.
core +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Cold water aquifer storage [PDF]
A working prototype system is described in which water is pumped from an aquifer at 70 F in the winter time, chilled to a temperature of less than 50 F, injected into a ground-water aquifer, stored for a period of several months, pumped back to the ...
Davison, R. R. +2 more
core +1 more source
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
Chemistry and Radiative Transfer of Water in Cold, Dense Clouds
, 2014 The Herschel Space Observatory's recent detections of water vapor in the cold, dense cloud L1544 allow a direct comparison between observations and chemical models for oxygen species in conditions just before star formation.
Caselli, Paola +2 more
core +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Spatial variation of soil quality in key grain-producing areas of Qitai County, Xinjiang
Guan'gai paishui xuebao【Objective】Qitai County, a major grain-producing area in Xinjiang, is adopting modern agricultural technologies such as aerial pest control, Beidou navigation, precision sowing, and integrated water-fertilizer management.
FAN Zikang +5 more
doaj +1 more source
Pathogenesis of sudden death following water immersion (immersion syndrome) [PDF]
Sympathetic activity under cold stress is investigated. Predominantly vagal cardio-depressive reflexes are discussed besides currently known mechanisms of sudden death after water immersion. Pronounced circulatory centralization in diving animals as well
Buhring, M., Spies, H. F.
core +1 more source