Results 21 to 30 of about 407,991 (167)

Sensitivity of cognitive composite scores to amyloid accumulation in emergent Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background In clinical trials for preclinical Alzheimer's disease (AD), cognition is the primary outcome and is measured by preclinical Alzheimer's disease cognitive composite (PACC) scores that combine data from neuropsychological tests of memory and executive function and clinical mental status.
Xia Y, Dore V, Fripp J, Bourgeat P, Lim Y, Robertson J, Rowe C, Masters C, Maruff P.   +8 more
europepmc   +2 more sources

Using AI to improve cross‐sectional and longitudinal Amyloid PET quantification: A validation study across 7 large cohorts [PDF]

Alzheimers Dement
Abstract Background Centiloid quantification relies on a Standardised Uptake Value Ratio (SUVR) that could be subject to noise, spill‐in, and specific binding in the reference region. We developed a novel deep learning method that learns scan‐specific variability from longitudinal trends to correct SUVR quantification and then validated it in 7 large ...
Bourgeat P, Fripp J, Gillman A, Cox T, Feizpour A, Xia Y, Zisis G, Goyal M, Tosun D, LaMontagne P, Benzinger T, Barkhof F, Farrar G, Bollack A, Sperling R, Morris J, Weiner M, Villemagne V, Masters C, Rowe C, Dore V.   +20 more
europepmc   +3 more sources

The best way to learn about urban design is to study great cities

Journal of Traditional Building, Architecture and Urbanism, 2020
Colin Rowe is remembered having said that, aside from buildings, there are several scales of architecture, which includes both “micro-architecture like furniture and silverware, and macro-architecture like London and Paris… well maybe more Paris than ...
Matthew Bell
doaj   +1 more source

Correlations of amyloid accumulation, brain atrophy and cognitive decline in emergent Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background Amyloid‐β (Aβ) deposition and dysfunction of the cholinergic basal forebrain (BF) system are early pathological features in Alzheimer's disease (AD). Given the continuous nature of Aβ accumulation, the extent of the corresponding changes in brain structure and cognitive performance at the emergent stage of AD, characterized by ...
Xia Y, Dore V, Fripp J, Bourgeat P, Lim Y, Laws S, Fowler C, Rowe C, Masters C, Coulson E, Maruff P.   +10 more
europepmc   +2 more sources

Combining Lumipulse pTau217 and Aβ42 as confirmatory tests for Aβ pathology prior to DMT [PDF]

Alzheimers Dement
Abstract Background With the increasing number of countries approving disease‐modifying therapies (DMTs) for patients with either Mild Cognitive Impairment (MCI) or mild Alzheimer's disease (AD), it is vitally important to streamline treatment assessment processes. Blood‐based biomarkers (BBMs) have been suggested as rivals to cerebrospinal fluid (CSF)
Doecke J, Chenna A, Lo M, Badal Y, Yee B, Martone R, Petropoulos C, Fowler C, Laws S, Rainey‐Smith S, Martins R, Rowe C, Masters C, Winslow J.   +13 more
europepmc   +2 more sources

La educación de un arquitecto en primer año: La malla de los nueve cuadrados y Architectonics de la Cooper Union

[i2]: Investigación e Innovación en Arquitectura y Territorio, 2021
La malla de los nueve cuadrados, el famoso ejercicio de John Hejduk, ha sido el proyecto más replicado del curso Architectonics de la Cooper Union. Este recurso pedagógico ha sido reproducido en diversas universidades del planeta. Esto puede deberse a la
Oscar Mauricio Pérez
doaj   +1 more source

Aldo van Eyck and the Rise of an Ethnographic Paradigm in the 1960s

Joelho, 2011
Aldo van Eyck e o surgimento de um paradigma etnográfico na década de 1960.   A comunicação inicia-se com a famosa introdução de Colin Rowe ao livro Five Architects (Nova Yorque, 1972), que refere uma citação de Aldo van Eyck publicada em Team 10 Primer (
Georges Teyssot
doaj   +1 more source

Some investigations and reflections around City of Composite Presence

piano b, 2020
The City of Composite Presence – an enigmatic drawing contained in Collage City – and the La città analoga – a panel displayed at the 1976 Venice Biennale – are icons of the architectural culture of the late seventies.
Nicola Braghieri
doaj   +1 more source

Two Faces of Contextualism: a Review of of Contextualism in a World with Chamfered Peaks and Valleys

Megaron, 2017
The present study is concerned with a body of studies in architecture called Contextualism. As its departure point, the study takes context and Contextualism as these concepts were defined in Collage City and in their conceptualizations between 1960s and
Ülkü Özten, Hakan Anay
doaj   +1 more source

A Review of Colin Rowe's Contextualism Through Twenty-first Century Cities

Megaron, 2020
The debate on context in architectural theory emerged as a response to how to integrate modern and historical patterns in the reconstruction of European cities bombed during World War II.
Ebru Bingol
doaj   +1 more source