Results 211 to 220 of about 31,699 (263)

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers

Advanced Science, EarlyView.
MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao, Cheng Lu, Hao Chen, Jing Zhou, Yunyun Hu, Haonan Di, Guoqiang Su, Xiaomei Yan   +7 more
wiley   +1 more source

Metabolic Regulation of Dimethylsulfoniopropionate Cleavage and Dimethyl Sulfide Production in Halomonas sp. D47

Advanced Science, EarlyView.
Dimethylsulfoniopropionate (DMSP) is a major marine organosulfur compound central to climate‐relevant dimethyl sulfide (DMS) production. In Halomonas sp. D47, DMSP catabolism is revealed to be coordinated by two transcriptional regulators, AcuR and AcuZ, which control gene expression by sensing DMSP and its metabolites.
Li‐Yuan Zheng, Wen‐Xin Jiang, Xiao‐Meng Sun, Li Liu, Zhao‐Jie Teng, Hou‐Qi Wang, Wen‐Jing Zhu, Chang Ge, Qi‐Long Qin, Ning‐Hua Liu, Hai‐Yan Cao, Hui‐Hui Fu, Chun‐Yang Li, Jonathan D. Todd, Xiu‐Lan Chen, Yu‐Zhong Zhang, Peng Wang   +16 more
wiley   +1 more source

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Collaborative Filtering

2011
The interactive tools like blogs, wikis, et cetera, known under the commonly acceptable name Web2.0, led to a new generation of Internet services and applications such as social networks, recommendation systems, reputation systems, et cetera, allowing for public participation in the formation of the content of the Web, and at the same time fueling an ...
Tania Al. Kerkiri, Dimitris Konetas
openaire   +2 more sources

Beyond Collaborative Filtering

Proceedings of the 25th International Conference on World Wide Web, 2016
Most Collaborative Filtering (CF) algorithms are optimized using a dataset of isolated user-item tuples. However, in commercial applications recommended items are usually served as an ordered list of several items and not as isolated items. In this setting, inter-item interactions have an effect on the list's Click-Through Rate (CTR) that is ...
Oren Sar Shalom, Noam Koenigstein, Ulrich Paquet, Hastagiri P. Vanchinathan   +3 more
openaire   +1 more source

Shared collaborative filtering

Proceedings of the fifth ACM conference on Recommender systems, 2011
Traditional collaborative filtering (CF) methods suffer from sparse or even cold-start problems, especially for new established recommenders. However, since there are now quite a few recommender systems already existing in good working order, their data should be valuable to the new-start recommenders. This paper proposes shared collaborative filtering
Yu Zhao, Xinping Feng, Jianqiang Li, Bo Liu   +3 more
openaire   +1 more source

Collaborative competitive filtering

Proceedings of the 34th international ACM SIGIR conference on Research and development in Information Retrieval, 2011
While a user's preference is directly reflected in the interactive choice process between her and the recommender, this wealth of information was not fully exploited for learning recommender models. In particular, existing collaborative filtering (CF) approaches take into account only the binary events of user actions but totally disregard the contexts
Shuang-Hong Yang, Bo Long, Alexander J. Smola, Hongyuan Zha, Zhaohui Zheng   +4 more
openaire   +1 more source

Improving Collaborative Filtering

2021 IV International Conference on Control in Technical Systems (CTS), 2021
In this paper, we experiment with a combination of metrics to calculate the similarity when creating collaborative filtering. The Otai Coefficient and Euclidean Distance are used, resulting in a recommender system that produces a satisfactory result.
Jurij A. Morozov, Sergej E. Saradgishvili   +1 more
openaire   +1 more source