Results 41 to 50 of about 225,764 (308)

STEP: From Collaboration to Innovation and from Innovation to Collaboration

Global Research in Higher Education, 2018
<em>Secondary Teacher Education Programme (STEP) is a collaborative program of the University College London’s Institute of Education and the Institute of Ismaili Studies in London. Qualitative research was undertaken to collect and analyse data.
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Exploring practices in collaborative innovation: Unpacking dynamics, relations, and enactment in in‐between spaces

, 2020
In the field of innovation management, the study of collaborative innovation has focused primarily on the type of networks to support innovation, the modularity of the products architecture required to engage actors in collaboration, the strategies for ...
Anna Yström, Agogue, Marine,, Agogue, Marine, Yström, Anna, Yström, Anna,, Marine Agogué   +5 more
core   +1 more source

Simulation Study on the Evolutionary Game Mechanism of Collaborative Innovation in Supply Chain Enterprises and Its Influencing Elements

Journal of Mathematics, 2021
Collaborative innovation between companies is critical for increasing supply chain value. However, as a dynamic game process, the collaboration between manufacturer, provider, and seller in the supply chain is influenced by a range of elements.
Jue-Ping Xie, Huai-Ying Lei
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Intellectual property and licensing strategies in open collaborative innovation

, 2011
Protecting intellectual property and controlling the use of their inventions is key to the strategy of many firms. At the same time, in order to be successful in open collaborative innovation, firms need to share their knowledge with others. This chapter
López Berzosa, D., Bekkers, R.N.A., Bogers, M., de Pablos Heredero, C., Granstrand, O.   +4 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Collaborative Innovation in Construction Supply Chain under Digital Construction: Evolutionary Game Analysis Based on Prospect Theory

Buildings
In the context of Digital Construction (DC), collaborative innovation in the construction supply chain (CSC) is crucial for long-term competitiveness. However, transparent information flows and fickle market circumstances hinder enterprises from actively
Chenyongjun Ding, Hui Liu, Yonghong Chen, Wenyi Qiu   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source