Results 61 to 70 of about 1,534,409 (324)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Baloxavir susceptibility of seasonal influenza viruses during the first seven seasons of clinical use in Japan, 2017/18 to 2023/24

Eurosurveillance
BACKGROUND: Baloxavir marboxil, a cap-dependent endonuclease inhibitor, was approved in Japan in February 2018 for treatment of influenza A and B infections, making Japan the first country to introduce its clinical use.AIM: We aimed to assess baloxavir ...
the Influenza Virus Surveillance Group of Japan
doaj   +1 more source

The Motives of Lithuanian Inhabitants to Enrol in Kaunas Self-defence Battalions in Summer and Autumn 1941

Genocidas ir Rezistencija, 2012
This article examines the biographical data of Lithuanian inhabitants who served during the Nazi occupation (1941-1944) in Kaunas National Labour Protection battalion (TDA), and in the Auxiliary Police Service (PPT) 1st and 2nd battalions, formed in ...
Alfredas Rukšėnas
doaj   +1 more source

ASPECTS REGARDING THE USE OF COLLABORATORS IN THE CRIMINAL TRIAL [PDF]

Challenges of the Knowledge Society, 2023
This work covers the review of the main issues arising in judicial practice with regard to the use of special surveillance or investigation methods, especially the use of undercover investigators and of collaborators, starting from ordering such measures
Mircea-Constantin SINESCU, Alin-Sorin NICOLESCU   +1 more
doaj  

Derivation of the linearity principle of Intriligator-Leigh-Seiberg [PDF]

, 2002
Utilizing the techniques recently developed for N=1 super Yang-Mills theories by Dijkgraaf, Vafa and collaborators, we derive the linearity principle of Intriligator, Leigh and Seiberg, for the confinement phase of the theories with semi-simple gauge ...
Tachikawa, Yuji
core   +2 more sources

Older care-home residents as collaborators or advisors in research: a systematic review

Age and Ageing, 2016
Background: patient and public involvement (PPI) in research can enhance its relevance. Older care-home residents are often not involved in research processes even when studies are care-home focused.
T. Backhouse, Andrea Kenkmann, K. Lane, B. Penhale, F. Poland, A. Killett   +5 more
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

From Hapless Victims to Collaborators: Exploring the Janus Voices of Women in the Aguleri-Umueri Conflict in Igboland, Southeast Nigeria

International Journal for Crime, Justice and Social Democracy
This article explores the Janus-faced voices of women in the Aguleri-Umueri communal conflicts, highlighting the contradictions inherent in their roles, not merely as victims but also as perpetrators and collaborators.
Daniel Olisa Iweze, Mary Nkechi Okadigwe   +1 more
doaj   +1 more source

Punitive Operations of Lithuanian Partisans in Lazdijai County in 1944–1952 (an example of Leipalingis rural district)

Genocidas ir Rezistencija, 2019
Judging by the whole of military conflicts that had taken place in Central Europe in the 20th century, the 1944–1952 resistance in Lithuania against the Soviet Union occupation distinguishes itself by relatively high indicators of collaborationism ...
Rimantas Zagreckas
doaj   +1 more source

Analytic Surgery of the zeta-determinant of the Dirac operator

, 2005
We review the work of the authors and their collaborators on the decomposition of the zeta-determinant of the Dirac operator into the contribution coming from different parts of a manifold.Comment: final ...
Atiyah, Atiyah, Atiyah, Bismut, Bojarski, Booβ-Bavnbek, Booβ-Bavnbek, Booβ-Bavnbek, Booβ-Bavnbek, Brünning, Burghelea, Cappell, Cheeger, Cheeger, Cheeger, Douglas, Gilkey, Grubb, Hassell, Hawking, Jinsung Park, Klimek, Krzysztof P. Wojciechowski, Lesch, Mazzeo, Müller, Müller, Müller, Nicolaescu, Palais, Park, Park, Park, Piazza, Piazza, Quillen, Ray, Scott, Scott, Scott, Seeley, Seeley, Segal, Singer, Singer, Taylor, Wojciechowski, Wojciechowski, Wojciechowski, Wojciechowski   +49 more
core   +1 more source