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Density–property relationships in collagen–glycosaminoglycan scaffolds

Acta Biomaterialia, 2010
Collagen-glycosaminoglycan scaffolds for the regeneration of skin have previously been fabricated by freeze-drying a slurry containing a co-precipitate of collagen and glycosaminoglycan. The mechanical properties of the scaffold are low (e.g. the dry compressive Young's modulus is roughly 30kPa and the dry compressive strength is roughly 5kPa).
Biraja P, Kanungo, Lorna J, Gibson
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Densities of collagen dehydrated by some organic solvents

Experientia, 1966
Der Einfluss von organischen Losungsmitteln auf die Dichteveranderungen des Kollagens wurde gepruft. Methanol und Butanol fuhrt zur Strukturauflockerung, Aceton und Dioxan zur Strukturverdichtung.
V, Podrazký, V, Sedmerová
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Density–property relationships in mineralized collagen–glycosaminoglycan scaffolds

Acta Biomaterialia, 2009
Mineralized collagen-glycosminoglycan scaffolds have previously been fabricated by freeze-drying a slurry containing a co-precipitate of calcium phosphate, collagen and glycosaminoglycan. The mechanical properties of the scaffold are low (e.g. the dry Young's modulus for a 50 wt.% mineralized scaffold is roughly 780 kPa).
Biraja P, Kanungo, Lorna J, Gibson
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Increased dermal collagen density in amyotrophic lateral sclerosis

Journal of the Neurological Sciences, 1988
We examined specimens of skin overlying the sacral region, among the most common sites of bedsores, from patients with amyotrophic lateral sclerosis (ALS) and controls, and found that in ALS patients, collagen fibrils had a greater density and became more tightly packed with the duration of illness.
S, Ono   +3 more
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Crosslinking density and resorption of dimethyl suberimidate‐treated collagen

Journal of Biomedical Materials Research, 1997
Collagen was purified from bovine Achilles tendon and crosslinked with dimethyl suberimidate (DMS) and glutaraldehyde (GTA). Under optimal conditions, the shrinkage temperature (Ts) was raised to 74 degrees C for collagen crosslinked with DMS and to 80 degrees C for those crosslinked with GTA.
V, Charulatha, A, Rajaram
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The distribution of electron density in corneal collagen fibrils

Current Eye Research, 1981
Using high intensity synchrotron X-ray diffraction data, an electron density profile has been obtained for the collagen fibrils in corneal stroma at higher resolution than has been possible before. The details within this electron density distribution are discussed in terms of the collagen and its interactions with other components present in the ...
K M, Meek   +3 more
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Collagen crosslinking and cell density have distinct effects on fibroblast‐mediated contraction of collagen gels

Skin Research and Technology, 2003
Background/purpose: Fibroblasts are actively and dynamically involved in wound healing (dermal regeneration, wound contraction, and scar contracture) and fibrosis. Fibroblast‐seeded collagen gels provide an in vitro model for these processes. Over time, fibroblasts will contract the gels, but the mechanisms are not completely understood. This research
Robert A, Redden, Edward J, Doolin
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Hydrodynamic Shear and Collagen Receptor Density Determine the Adhesion Capacity of S. aureus to Collagen

Annals of Biomedical Engineering, 2001
Dynamic bacterial adhesion has recently gained significant attention due to its role in the initiation of infectious diseases. Staphylococcus aureus binding to collagen has been shown to be an important event in the pathogenesis of infection. Staphylococcal strains have exhibited wide variability in their level of collagen binding, which may be a ...
L, Mascari, J M, Ross
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Fabrication of high-density collagen fibril matrix gels by renaturation of triple-helix collagen from gelatin

International Journal of Biological Macromolecules, 2013
Collagen-based 3-D hydrogels often lack sufficient mechanical strength for tissue engineering. We developed a method for fabrication of high-density collagen fibril matrix (CFM) gels from concentrated solutions of uncleaved gelatin (UCG). Denatured random-coil UCG exhibited more rapid and efficient renaturation into collagen triple-helix than cleaved ...
Yoshimi, Ohyabu   +3 more
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