Results 71 to 80 of about 437,388 (294)

Serial T1 mapping of right ventricle in pulmonary hypertension: comparison with histology in an animal study

Journal of Cardiovascular Magnetic Resonance, 2021
Background Right ventricular (RV) free wall fibrosis is an important component of adverse remodeling with RV dysfunction in pulmonary hypertension (PH).
Pan Ki Kim, Yoo Jin Hong, Hyo Sub Shim, Dong Jin Im, Young Joo Suh, Kye Ho Lee, Jin Hur, Young Jin Kim, Byoung Wook Choi, Hye-Jeong Lee   +9 more
doaj   +1 more source

Is there a role for vitamin C in preventing osteoporosis and fractures?:A review of the potential underlying mechanisms and current epidemiological evidence [PDF]

, 2014
Osteoporosis and related fractures are a major global health issue, but there are few preventative strategies. Previously reported associations between higher intakes of fruits and vegetables and skeletal health have been suggested to be partly ...
Ailsa A. Welch, Amy Jennings, Andrew R. Hart, Bates, Bates, Canoy, Drewnowski, Gottlieb, Henriette Finck, Hill, Hoffer, Kaptoge, Lanham-New, Myllyla, New, New, Otsuka, Pradel, Prynne, Sahni, Scrimshaw, Sowers, Tucker, Wolf   +23 more
core   +1 more source

The Proteoglycan Decorin Links Low Density Lipoproteins with Collagen Type I [PDF]

Journal of Biological Chemistry, 1997
Decorin is a small dermatan sulfate-rich proteoglycan which binds to collagen type I in vitro and in vivo. In atherosclerotic lesions the contents of low density lipoprotein (LDL), decorin, and collagen type I are increased, and ultrastructural studies have suggested an association between LDL and collagen in the lesions.
M O, Pentikäinen, K, Oörni, R, Lassila, P T, Kovanen   +3 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Transglutaminase 2 in human peritoneal dialysis‐related peritoneal injury

Physiological Reports
Patients undergoing long‐term peritoneal dialysis (PD) frequently develop peritoneal fibrosis and angiogenesis, leading to membrane dysfunction. Transglutaminase 2 (TG2) stabilizes the extracellular matrix against proteases.
Shunnosuke Kunoki, Masashi Ikeno, Hideki Tatsukawa, Yukinao Sakai, Hiroshi Kinashi, Keisuke Kamiya, Masafumi Suzuki, Masashi Mizuno, Makoto Yamaguchi, Hiroyuki Sasakura, Yuki Morioka, Masataka Banshodani, Mitsuhiro Tawada, Masato Iwabu, Takuji Ishimoto, Kosei Takeuchi, Kiyotaka Hitomi, Hideki Kawanishi, Yasuhiko Ito   +18 more
doaj   +1 more source

Comparison between High Cell-Density Culture Systems for Chondrogenic Differentiation and Articular Cartilage Reconstruction of Human Mesenchymal Stem Cells: A Literature Review

Regeneration, Reconstruction & Restoration, 2017
High-cell density culture is based on the chondrogenic differentiation of human mesenchymal stem cells (hMSCs), and because the high density of cell and reduced oxygen tension are effective in chondrogenic differentiation.
Hossein Mahboudi, Bahram Kazemi, Hana Hanaee-Ahvaz, Abdolreza Ardeshirylajimi, Mohamad Eftekhary, Seyed Ehsan Enderami   +5 more
doaj   +1 more source

Postnatal development of depth-dependent collagen density in ovine articular cartilage [PDF]

BMC Developmental Biology, 2010
AbstractBackgroundArticular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Adult AC is characterised by a depth-dependent composition and structure of the extracellular matrix that results in depth-dependent mechanical properties, important for the functions of adult AC. Collagen is the most
van Turnhout, M.C., Schipper, H., van Lagen, B., Zuilhof, H., Kranenbarg, S., van Leeuwen, J.L.   +5 more
openaire   +3 more sources

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]

, 2015
The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P., Gronau, Julian H., King, Helen, Rodriguez-Teja, Mercedes, Shah, Neel, Sturge, Justin, Wang, Kai, Waxman, Jonathan   +7 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Poly-l/dl-lactic acid films functionalized with collagen IV as carrier substrata for corneal epithelial stem cells [PDF]

, 2019
Limbal epithelial stem cells (LESCs) are responsible for the renewal of corneal epithelium. Cultivated limbal epithelial transplantation is the current treatment of choice for restoring the loss or dysfunction of LESCs.
Calonge Cano, Margarita, Engel, Elisabeth, Galindo de la Rosa, Sara, López Paniagua, Marina, Mata Sampedro, Ana de la, Mateos Timoneda, Miguel Ángel, Nieto Miguel, Teresa, Planell, Josep A.   +7 more
core   +3 more sources