Results 201 to 210 of about 333,763 (263)

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Nonlinear Imaging Allows to Characterize Granulomas and Fibrosis in Mice Tissue From Experimental Schistosomiasis. [PDF]

J Biophotonics
da Fonseca GR, Lima RRM, Soares RE, Ribeiro BRM, Cabral Filho PE, Fontes A, de Paula AM.   +6 more
europepmc   +1 more source

[Epidemiology of collagen diseases. (1). Screening of collagen diseases].

Nihon eiseigaku zasshi. Japanese journal of hygiene, 1975
F, Yanagisawa, M, Oyama, H, Oba, Y, Matsuoka, H, Kurihara   +4 more
openaire   +1 more source

RPE With ROCK-Mediated Epithelial-Mesenchymal Transition as a Key Contributor of Subretinal Fibrosis in AMD. [PDF]

Invest Ophthalmol Vis Sci
Wada I, Ishikawa K, Yamaguchi M, Shimokawa S, Rui J, Mori K, Kaizu Y, Arima M, Notomi S, Murakami Y, Inagaki S, Kohro Y, Tsuda M, Shibata K, Terao R, Terabayashi T, Ishizaki T, Yoshida S, Ishibashi T, Ishida S, Apte RS, Sonoda KH, Nakao S.   +22 more
europepmc   +1 more source

Quantitative second harmonic generation microscopy for characterizing collagen remodeling in papillary thyroid carcinoma. [PDF]

J Biomed Opt
Poon W, Wang L, Davarci O, Master R, Zhao H, Liu J, Khadra HS, Jacobi EM, Raghunathan R, Wong STC.   +9 more
europepmc   +1 more source

The glomerulus in bloom- ultrastructural tapestry of collagenofibrotic glomerulopathy. [PDF]

BMC Nephrol
Večerić-Haler Ž, Pleško J, Kojc N.
europepmc   +1 more source

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Heritable Diseases of Collagen

New England Journal of Medicine, 1984
FOR several decades it has been apparent that many diseases directly or indirectly involve collagen, the tough fibrous material that is the most abundant protein in the body and the major constitue...
Prockop Darwin J, Kari I Kivirikko, D J Prockop   +2 more
exaly   +3 more sources

Collagen Diseases and the Biosynthesis of Collagen

Hospital Practice, 1977
Increasing knowledge concerning the molecular structure of collagen and the steps involved in its biosynthesis provides the basis for a new look at the collagen diseases. Some, like the Ehlers-Danlos syndrome, are now known to be the expression of primary molecular defects; others, such as scurvy and scleroderma, appear to be secondary to some process ...
D J, Prockop, N A, Guzman
openaire   +2 more sources

Collagen Vascular Disease

Dermatologic Clinics, 1992
The iatrogenic L-tryptophan-induced eosinophilia-myalgia syndrome, often considered to be a "new" disease, has proven to be a remarkable mimic of the classic sclerosing rheumatologic disorders. Although subacute cutaneous lupus erythematosus remains a clinically defined entity, supportive histologic and immunopathologic findings have recently been ...
J D, DeSpain, R W, Swinfard
openaire   +2 more sources