Results 31 to 40 of about 90,716 (261)

Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer

Bioengineering, 2021
Recent research has highlighted the importance of key tumor microenvironment features, notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and progression.
Jonathan N. Ouellette, Cole R. Drifka, Kelli B. Pointer, Yuming Liu, Tyler J Lieberthal, W John Kao, John S. Kuo, Agnes G. Loeffler, Kevin W. Eliceiri   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women.

PLoS ONE, 2016
The structural integrity of the cervix in pregnancy is necessary for carrying a pregnancy until term, and the organization of human cervical tissue collagen likely plays an important role in the tissue's structural function.
Wang Yao, Yu Gan, Kristin M Myers, Joy Y Vink, Ronald J Wapner, Christine P Hendon   +5 more
doaj   +1 more source

SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament. [PDF]

PLoS ONE, 2017
The periodontal ligament (PDL) is a fibrous connective tissue that anchors tooth cementum into alveolar bone. Secreted protein acidic and rich in cysteine (SPARC) is a collagen-binding matricellular protein known to influence collagen fiber assembly in ...
Emilie Moore Rosset, Jessica Trombetta-eSilva, Glenn Hepfer, Hai Yao, Amy Dodd Bradshaw   +4 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Templated Assembly of Collagen Fibers Directs Cell Growth in 2D and 3D

Scientific Reports, 2017
Collagen is widely used in tissue engineering and regenerative medicine, with many examples of collagen-based biomaterials emerging in recent years.
G. Y. Liu, R. Agarwal, K. R Ko, M. Ruthven, H. T. Sarhan, J. P. Frampton   +5 more
doaj   +1 more source

Acoustic modification of collagen hydrogels facilitates cellular remodeling

Materials Today Bio, 2019
Developing tunable biomaterials that have the capacity to recreate the physical and biochemical characteristics of native extracellular matrices (ECMs) with spatial fidelity is important for a variety of biomedical, biological, and clinical applications.
E.G. Norris, D. Dalecki, D.C. Hocking
doaj   +1 more source

Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue

Frontiers in Bioengineering and Biotechnology, 2021
Solid tumor progression is significantly influenced by interactions between cancer cells and the surrounding extracellular matrix (ECM). Specifically, the cancer cell-driven changes to ECM fiber alignment and collagen deposition impact tumor growth and ...
Rakesh Gurrala, Rakesh Gurrala, C. Ethan Byrne, Loren M. Brown, Rafael Felix P. Tiongco, Rafael Felix P. Tiongco, Margarite D. Matossian, Margarite D. Matossian, Jonathan J. Savoie, Bridgette M. Collins-Burow, Matthew E. Burow, Matthew E. Burow, Elizabeth C. Martin, Frank H. Lau   +13 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Identification of prognostic collagen signatures and potential therapeutic stromal targets in canine mammary gland carcinoma. [PDF]

PLoS ONE, 2017
Increasing evidence indicates that the tumor microenvironment plays a critical role in regulating the biologic behavior of breast cancer. In veterinary oncology, there is a need for improved prognostic markers to accurately identify dogs at risk for ...
Ashley Case, Becky K Brisson, Amy C Durham, Suzanne Rosen, James Monslow, Elizabeth Buza, Pascale Salah, Julie Gillem, Gordon Ruthel, Sridhar Veluvolu, Veronica Kristiansen, Ellen Puré, Dorothy C Brown, Karin U Sørenmo, Susan W Volk   +14 more
doaj   +1 more source