Results 161 to 170 of about 5,562 (218)

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

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Type III collagen and probably not type I collagen aggregates platelets

Thrombosis Research, 1976
Abstract Type I collagen and type III collagen were extracted from foetal calf skin and used for inducing platelets aggregation in vitro . When added under its soluble form, type III collagen was found to be a faster and a most powerful platelet aggregating factor.
J, Hugues, F, Hérion, B, Nusgens, C M, Lapière   +3 more
openaire   +2 more sources

Difference in interaction of fibronectin with type I collagen and type IV collagen

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1997
In our studies on fibronectin, difference in binding to type I collagen and type IV collagen was observed and analysed. Four different fragments, which consist of I6-II1-II2-I7-I8-I9, I6-II1-II2-I7, I6-II1-II2, and I8-I9 within the collagen binding domain, have been isolated from proteolytic digests of fibronectin.
M, Shimizu, K, Minakuchi, M, Moon, J, Koga   +3 more
openaire   +2 more sources

Reduced thrombogenicity of type VI collagen as compared to type I collagen

Thrombosis Research, 1995
Type VI collagen has been recently identified as a major constituent of vascular subendothelium where it serves as a binding site for von Willebrand factor. The present study compares the functional characteristics of type VI collagen with those of type I collagen with respect to platelet aggregating and secretory activities.
M, Zangari, K L, Kaplan, R W, Glanville, J H, Rand   +3 more
openaire   +2 more sources

Glycosylation of Type I Collagen

2019
Fibrillar type I collagen is the most abundant structural protein in most tissues and organs. One of the unique and functionally important characteristics of collagen is sequential posttranslational modifications of lysine (Lys) residues. In the endoplasmic reticulum, hydroxylation of specific Lys occurs producing 5-hydroxylysine (Hyl).
Mitsuo, Yamauchi, Marnisa, Sricholpech, Masahiko, Terajima, Kenneth B, Tomer, Irina, Perdivara   +4 more
openaire   +2 more sources

Hydroperoxide formation in model collagens and collagen type I

International Journal of Cosmetic Science, 2002
SynopsisProtein hydroperoxides represent a relatively new concept in understanding biological oxidation chemistry. Here, we show with post‐column‐chemiluminescence that this sometimes remarkably stable and yet reactive species can be formed in collagen models and collagen type I when submitted to oxidative stress as exemplified by the Fenton reaction ...
S A, Madison, J E B, McCallum, R U, Rojas Wahl   +2 more
openaire   +2 more sources

In vitro Formation of Hybrid Fibrils of Type v Collagen and Type I Collagen Limited Growth of Type I Collagen Into Thick Fibrils by Type V Collagen

Connective Tissue Research, 1986
Type V collagen and type I collagen were obtained from human placentas by pepsin treatment, followed by salt fractionation. The precipitates formed at 37 degrees C from a mixed solution of type V collagen and type I collagen, reacted with antibodies to either type V collagen or type I collagen.
E, Adachi, T, Hayashi
openaire   +2 more sources

Improvement of the Material Property of Shark Type I Collagen by Composing with Pig Type I Collagen

Journal of Agricultural and Food Chemistry, 2000
Fibril reconstruction process, that is, the nucleation and growth of mixed type I collagen fibril of shark and pig, progressed faster than that of the individual collagen species of shark or pig. The reconstructed mixed collagen fibril had a greater resistance to return to the solution or to melt into gelatin in comparison with the counterpart ...
Y, Nomura, S, Toki, Y, Ishii, K, Shirai
openaire   +2 more sources