Results 51 to 60 of about 7,980,398 (271)

Investigating the impact of imperfections around a wellbore on liner deformation during hydraulic fracturing

Frontiers in Mechanical Engineering
It is essential to maintain the integrity of liner–cement–formation in the well completion and production stages. However, large liner deformations have been extensively experienced during hydraulic fracturing operations in carbonate formations.
Yanhui Han, Dung Phan, Younane Abousleiman, Khalid Ruwaili   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Prediction and Application of Pore Pressure in Guangming Structure Formation of Hetao Basin

Cejing jishu
To ensure drilling safety and optimize reservoir evaluation in ultra-deep and high-pressure formations of the Guangming structure in the Hetao basin, solve accidents such as overflow and collapse caused by inaccurate pore pressure prediction, and support
YU Weigao, DAI Hongxia, LI Xiaofeng, SHI Yanfei, FU Shaoqing, HAN Xianming, HU Shaohua, HE Zhiming   +7 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Empirical Formula for Estimating Collapse Pressure of Dented Sandwich Pipes

Journal of Marine Science and Engineering
Deepwater sandwich pipes (SPs) offer high collapse resistance and thermal insulation, making them promising for hydrocarbon transport under high-pressure and low-temperature conditions.
Zijian Zheng, Yihao Hu, Guangming Fu, Ming Song, Segen F. Estefen   +4 more
doaj   +1 more source

Analysis of Collapse Pressure Performance of Ultra-High Pressure Perforating Gun under Different Blind Hole Depths

Shiyou jixie, 2021
For the blind hole depth, outer diameter ellipticity and wall thickness unevenness that affect the collapse performance of ultra-high pressure perforating gun, an ideal geometric model and a model with geometric defects of ultra-high pressure perforating
Wang Qiang, Zhou Xinyi, Chao Lining, Jiao Wei, Yuan Qingying, Yang Xiaolong   +5 more
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

An empirical formula for predicting the collapse strength of composite cylindrical-shell structures under external pressure loads

Ocean Engineering, 2019
This paper derives an empirical formula for predicting the collapse strength of composite cylindrical-shell structures under external hydrostatic pressure loads as a function of geometric dimensions and layered angles, where the effects of initial ...
Y. Cho, Dohan Oh, J. Paik
semanticscholar   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The buckling and collapse behaviour of saddle-supported cylinders - Keynote Lecture [PDF]

, 2003
Recent work by the present authors on the collapse conditions for horizontal cylindrical saddle supported storage vessels is described and reviewed. Attention is directed to a range of geometries, typically R/t < 200, where plastic collapse type failure ...
Spence, J., Nash, D.H.
core   +3 more sources