Results 51 to 60 of about 508,943 (271)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Journal of Mosaic Research, 2018 Tamed and domesticated carnivores such as dogs, cheetahs and mongooses participated as search and chase aids to human hunting in different societies, during most of history, as attested by anthropological, literary or graphic sources.
Amir GORZALCZANY, Baruch ROSEN
doaj +1 more source
How do Companies Communicate with Nonexempt/Offline/Non-Desk Employees and Keep Them Confident and Engaged During Times of Organizational Change? [PDF]
, 2017 [Excerpt] Companies have had to evolve continuously to remain competitive in today’s marketplace. Especially in industries with blue-collar workers, automation and other forms of innovation have become looming stress points to many employees. Maintaining
Tsui, Amelia
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
System for testing bearings [PDF]
, 1993 Disclosed here is a system for testing bearings wherein a pair of spaced bearings provides support for a shaft on which is mounted a bearing to be tested, this bearing being mounted in a bearing holder spaced from and in alignment with the pair of ...
Gibson, John C.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Comparison of Symmetrical and Unsymmetrical Rectangular Collars on Reduction of Local Scour at Bridge Abutment [PDF]
علوم و مهندسی آبیاری, 2014 Already many studies have been done on the mechanism of scour around hydraulic structure especially bridges and methods for control or reduction of scour around them have been investigated and evaluated.
Hossein Khozeymehnezhad +2 more
doaj
Metallic threaded composite fastener [PDF]
, 1992 A metallic threaded composite fastener, particularly suited for high temperature applications, has a body member made of high temperature resistant composite material with a ceramic coating.
Dunn, Thomas J.
core +1 more source
Frontiers in Physiology, 2012 Much effort has gone into elucidating control of the body by the brain, less so the role of the body in controlling the brain. This essay develops the idea that the brain does a great deal of work in the service of behavior that is controlled by the body, a blue-collar role compared to the white-collar control exercised by the body.
Van Orden, Guy +2 more
openaire +5 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source