Results 71 to 80 of about 508,124 (272)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

ILR Impact Brief - Phased Retirement: Opportunities for Some but Not for All [PDF]

, 2006
Nearly three-quarters of employers surveyed indicate that some form of phased retirement could be worked out for white-collar employees aged 55 and older.
Chen, Jennjou, Hutchens, Robert M.
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Firms’ moral hazard in sickness absences [PDF]

Sick workers in many countries receive sick pay during their illness- related absences from the workplace. In several countries, the social security system insures firms against their workers’ sickness absences.
René Böheim, Thomas Leoni
core   +6 more sources

Betrayed Auto Retirees, Blue-Collar & White-Collar [PDF]

, 2009
This article is part of the collection of writings of Marshall (Mike) Westfall, retired autoworker from General Motors in Flint, Michigan (1964-1994) and activist critic of the auto industry restructuring that led to devastating job losses. It originally
Westfall, Marshall (Mike)
core   +1 more source

Particle Physics Implications for CoGeNT, DAMA, and Fermi

, 2010
Recent results from the CoGeNT collaboration (as well as the annual modulation reported by DAMA/LIBRA) point toward dark matter with a light (5-10 GeV) mass and a relatively large elastic scattering cross section with nucleons (\sigma ~ 10^{-40} cm^2 ...
Aad, Aalseth, Aaltonen, Abazajian, Ahmed, Akerib, Andreas, Angle, Bae, Barger, Barger, Belikov, Beltran, Bernabei, Boehm, Boehm, Boehm, Borriello, Boyarsky, Chang, Cline, Collar, Collar, Collar, Collar, Collar, Collar, Crocker, Dan Hooper, Draper, Drukier, Essig, Feldman, Fitzpatrick, Fitzpatrick, Gelmini, Gondolo, Goodman, Goodman, Graham, Gunion, Han, Hooper, Hooper, Hooper, Kang, Kopp, Krolikowski, Kuflik, Lavalle, Lisanti, Logan, Matthew R. Buckley, Nakamura, Petriello, Schael, Sorensen, Tim M.P. Tait   +57 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Review of Collars, Harnesses, and Head Collars for Walking Dogs

Animals
As dogs are often required to be leashed in public, guardians need to choose between various restraint devices. While using collars typically considered aversive (such as choke, prong, or electric collars) is generally discouraged due to welfare concerns,
Camila Cavalli, Alexandra Protopopova
doaj   +1 more source

Redundancies in an industry in transition: who gets fired and why? Evidence from one consumer-goods industry in Russia [PDF]

Does employee productivity explain why during a period of crisis firms fired relatively more blue-collar than white-collar workers and why, when conditions improved, they began to hire relatively more blue collars?
Rinaldi, Gustavo
core   +1 more source

Collared and non-collared manifold boundaries

L’Enseignement Mathématique, 2022
We gather in this note results and examples about collared and non-collared boundaries in non-metrisable manifolds. It has been known for a long time that boundaries are collared in metrisable manifolds, but the matter is more complicated for non-metrisable ones.
openaire   +2 more sources