Results 71 to 80 of about 508,943 (271)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Collared versus collarless hydroxyapatite-coated stems for primary cementless total hip arthroplasty; a systematic review of comparative studies. Is there any difference in survival, functional, and radiographic outcomes?

SICOT-J
Introduction: This systematic review aims to critically assess the literature comparative studies investigating collared and collarless Corail stem in primary total hip arthroplasty (THA) to find differences in revision rates, radiographic and clinical ...
Giovanoulis Vasileios, Kenanidis Eustathios, Aïm Florence, Gamie Zakareya, Marmor Simon, Potoupnis Michael, Lustig Sébastien, Tsiridis Eleftherios   +7 more
doaj   +1 more source

INVESTIGATION OF TOLERABILITY OF COMPLEX ANTIPARASITIC DRUG «INSPECTOR COLLAR»

Российский паразитологический журнал, 2016
Objective of research: To evaluate the tolerability of the drug, “Inspector Collar” based on Fipronil, Pyriproxyfen and Ivermectin in dogs and cats applied at a therapeutic dose and double increased therapeutic doses.Materials and methods: Research was ...
M. V. Arisov, I. G. Glamazdin, A. I. Dyomin, V. V. Artemov   +3 more
doaj   +1 more source

Particle Physics Implications for CoGeNT, DAMA, and Fermi

, 2010
Recent results from the CoGeNT collaboration (as well as the annual modulation reported by DAMA/LIBRA) point toward dark matter with a light (5-10 GeV) mass and a relatively large elastic scattering cross section with nucleons (\sigma ~ 10^{-40} cm^2 ...
Aad, Aalseth, Aaltonen, Abazajian, Ahmed, Akerib, Andreas, Angle, Bae, Barger, Barger, Belikov, Beltran, Bernabei, Boehm, Boehm, Boehm, Borriello, Boyarsky, Chang, Cline, Collar, Collar, Collar, Collar, Collar, Collar, Crocker, Dan Hooper, Draper, Drukier, Essig, Feldman, Fitzpatrick, Fitzpatrick, Gelmini, Gondolo, Goodman, Goodman, Graham, Gunion, Han, Hooper, Hooper, Hooper, Kang, Kopp, Krolikowski, Kuflik, Lavalle, Lisanti, Logan, Matthew R. Buckley, Nakamura, Petriello, Schael, Sorensen, Tim M.P. Tait   +57 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Toxicological Evaluation of the Complex Insectoacaricidal Preparation "Neoterika Protecto 12"

Российский паразитологический журнал, 2019
The purpose of the research: toxicological evaluation of a medicinal product for veterinary use "Neoterica Protecto 12" on laboratory animals. Materials and methods. White outbred rats, mice and guinea pigs were used in the experiment.
E. N. Indyuhova, M. V. Arisov, G. B. Arisova, I. A. Stepanova   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Wherefore Art Thou Guidelines? An Empirical Study of White-Collar Criminal Sentencing and How the Gall Decision Effectively Eliminated the Sentencing Guidelines [PDF]

, 2008
[Excerpt] “Until the passage of the U.S. Federal Sentencing Guidelines in 1984, federal judges had relatively wide discretion in sentencing federal offenders up to the statutory maximum.
Morin, S. Patrick
core   +1 more source

Collared and non-collared manifold boundaries

L’Enseignement Mathématique, 2022
We gather in this note results and examples about collared and non-collared boundaries in non-metrisable manifolds. It has been known for a long time that boundaries are collared in metrisable manifolds, but the matter is more complicated for non-metrisable ones.
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source