Results 81 to 90 of about 508,124 (272)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Ученые записки Казанского университета: Серия Гуманитарные наукиThis article explores the perception of the yoke as a symbol of domination and subordination in texts from Ancient Mesopotamia and the Middle East, as well as from ancient Greek and Roman writings.
Е. V. Rung, Е. A. Venidiktova
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
نشریه مهندسی دریا, 2015 Nowadays, the power industry with fixed offshore wind turbines through the renewable energies is one of the progressing industries. The installation of scour protection structures is done against the scouring process.
Reza Yazdani +2 more
doaj
Analysing the Gender Wage Gap Using Personnel Records of a Large German Company [PDF]
We use monthly personnel records of a large German company to analyse the gender wage gap (GWG). Main findings are: (1) the unconditional GWG is 15 percent for blue-collar and 26 percent for white-collar workers; (2) conditional on tenure, entry age ...
Pfeifer, Christian, Sohr, Tatjana
core
Wherefore Art Thou Guidelines? An Empirical Study of White-Collar Criminal Sentencing and How the Gall Decision Effectively Eliminated the Sentencing Guidelines [PDF]
, 2008 [Excerpt] “Until the passage of the U.S. Federal Sentencing Guidelines in 1984, federal judges had relatively wide discretion in sentencing federal offenders up to the statutory maximum.
Morin, S. Patrick
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Recent Results from the SIMPLE Dark Matter Search
, 2005 SIMPLE is an experimental search for evidence of spin-dependent dark matter, based on superheated droplet detectors using C$_{2}$ClF$_{5}$. We report preliminary results of a 0.6 kgdy exposure of five one liter devices, each containing $\sim$10 g active ...
Collar, J. I., Girard, TA, Giuliani, F.
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Journal for Transdisciplinary Research in Southern Africa, 2007 In this article, two contrasting theories on the attitudes of unskilled blue collar workers are confronted: the ‘embourgeoisement’ thesis and the hypothesis of the ‘authoritarianism of the working class’.
Hans De Witte
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source