Results 101 to 110 of about 34,897 (281)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Effect of vasopressin analogue (dDAVP) on potassium transport in medullary collecting duct [PDF]

, 1987
The microcatheterization technique was used to examine electrolyte transport in the medullary collecting duct of two groups of anesthetized rats during water diuresis and during a second experimental phase with 1-desamino-8-D-arginine vasopressin (dDAVP)
U. Honrath, D. R. Wilson, H. Sonnenberg
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Collecting duct (Bellini duct) renal cell carcinoma: a clinical case and literature review

Вестник урологии
A rare subtype of renal cell carcinoma (RCC) is Bellini collecting duct carcinoma, also known as medullary renal carcinoma or distal nephron carcinoma, which accounts for 0.4-2.0% of all RCC cases.
N. I. Sorokin, V. E. Sinitsyn, O. A. Kharlova, A. A. Strigunov, O. Yu. Nesterova, R. A. Nikoghosyan, E. A. Galliamov, A. A. Kamalov   +7 more
doaj   +1 more source

Extrarenal multiorgan metastases of collecting duct carcinoma of the kidney: A case series

Journal of Medical Case Reports, 2008
Introduction Collecting duct carcinoma is a rare type of renal cell carcinoma. The primary is difficult to diagnose on imaging, and metastases are often present on initial presentation.
Nakamura Hisao, Kuirhara Yasuyuki, Matsushita Kazuhiko, Sakai Akehide, Yamaguchi Toshio, Nakajima Yasuo   +5 more
doaj   +1 more source

Collecting duct carcinoma: A rare malignancy

Journal of Cancer Research and Therapeutics, 2013
A 45-years old man complained of hematuria, and subsequent examination and ultrasonography revealed a mass in the left kidney. Nephrectomy was performed and macroscopically an ill-defined pale-cream, irregular mass was identified which occupied predominantly the renal medulla. Histopathologic examination showed slit like tubular ducts lined by atypical
Debdas, Bose, Ram N, Das, Uttara, Chatterjee, Uma, Banerjee   +3 more
openaire   +2 more sources

Cellular morphology in outer medullary collecting duct: effect of 75% nephrectomy and K+ depletion [PDF]

, 1992
The present study was designed to determine, in rats, whether 75% nephrectomy and potassium depletion affect the principal and intercalated cells in the outer medullary collecting duct in the same manner as they affect the principal and intercalated ...
D. A. Henderson, R. K. Zalups
core   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Genetic Deletion of P2Y2 Receptor Offers Long-Term (5 Months) Protection Against Lithium-Induced Polyuria, Natriuresis, Kaliuresis, and Collecting Duct Remodeling and Cell Proliferation

Frontiers in Physiology, 2018
Chronic lithium administration for the treatment of bipolar disorder leads to nephrogenic diabetes insipidus (NDI), characterized by polyuria, natriuresis, kaliuresis, and collecting duct remodeling and cell proliferation among other features. Previously,
Yue Zhang, Yue Zhang, Yue Zhang, Anne Riquier-Brison, Anne Riquier-Brison, Tao Liu, Tao Liu, Yufeng Huang, Noel G. Carlson, Noel G. Carlson, Noel G. Carlson, János Peti-Peterdi, János Peti-Peterdi, Bellamkonda K. Kishore, Bellamkonda K. Kishore, Bellamkonda K. Kishore, Bellamkonda K. Kishore   +16 more
doaj   +1 more source

GRHL2 is required for collecting duct epithelial barrier function and renal osmoregulation [PDF]

, 2018
Collecting ducts make up the distal-most tubular segments of the kidney, extending from the cortex, where they connect to the nephron proper, into the medulla, where they release urine into the renal pelvis.
Walentin, K., Himmerkus, N., Wiig, H., Hinze, C., Yurtdas, Z.Y., Schmidt-Ott, K.M., Nikpey, E., Klein, J.D., Tenstad, O., Branchi, F., Sands, J.M., Bleich, M., Bachmann, S., Schumann, M., Ruffert, J., Mutig, K.   +15 more
core   +1 more source