Results 81 to 90 of about 9,409 (259)

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Characterization of the extracellular matrix from human and dog umbilical cords

The Anatomical Record, EarlyView.
Abstract The extracellular matrix is important for maintaining tissue morphogenesis and homeostasis; it can also be used as a biomaterial for the production of biological scaffolds. Particularly, the umbilical cord has shown potential in the production of scaffolds for small‐diameter vessels.
Ana Carla Mendonça, Roberta Losi Guembarovski, Carlos Alberto Miqueloto, Alda Fiorina Maria Losi Guembarovski, Caio Garcia Barbosa da Silva, Laís Capelasso Lucas Pinheiro, Phelipe Oliveira Favaron   +6 more
wiley   +1 more source

COLLECTING DUCT CARCINOMA OF THE KIDNEY: REPORT OF TWO CASES

Urology Research and Practice, 2019
Introduction: Collecting duct carcinoma is a rare neoplasm of the kidney. It is highly aggressive and life expectancy of patients is usually very poor. For the majority of patients, surgical treatment will not result in cure.
Tahsin TURUNÇ, Filiz Bulat, Tulga EĞİLMEZ, Sezgin Güvel, Hakan ÖZKARDEŞ   +4 more
doaj   +2 more sources

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Immunohistochemical Analysis of SMARCB1/INI-1 Expression in Collecting Duct Carcinoma

, 2011
OBJECTIVES Collecting duct carcinoma (CDC) is a rare and aggressive renal tumor with a tendency to involve the renal sinus. CDC displays variable morphologic features that can overlap with those of renal medullary carcinoma.
George J. Netto, Alcides Chaux, Luciana Schultz, Illei, Peter B., Epstein, Jonathan I., Elwood, Hillary, Athanase Billis, Argani, Pedram, Rajni Sharma, Billis, Athanase, Netto, George J., Baydar, Dilek E., Peter B. Illei, Chaux, Alcides, Hillary Elwood, Schultz, Luciana, Pedram Argani, Sharma, Rajni, Dilek E. Baydar, Jonathan I. Epstein   +19 more
core   +1 more source

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Collecting Duct Carcinoma With Cardiac Metastases: A Case Report & Literature Review

Urology Case Reports, 2016
Collecting duct carcinoma (CDC), is a rare and aggressive form of renal cell carcinoma (RCC) accounting for around 1% of all renal malignancy. It affects younger patients and is associated with rapid progression, distant spread and poor prognosis ...
James N. Voss, Nkwam M. Nkwam, Thomas A. McCulloch, Gurminder S. Mann   +3 more
doaj   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Collecting duct carcinoma of the kidney associated with the sickle cell trait

, 2001
Collecting duct carcinoma of the kidney is a rare neoplasm that arises from the medullary collecting ducts. It has an aggressive clinical course and patients usually present with metastatic disease.
Harper, P, Al-Nawab, M, Yip, D, Steer, C, van der Walt, J   +4 more
core  

Collecting duct carcinoma appearing as a hepatic hydatid cyst. A rare case report [PDF]

, 2020
George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, The 8th International Medical Congress for Students and Young Doctors, September 24-26, 2020Background. Collecting duct carcinoma is located in the renal medulla
Emőke, Drágus, Zsolt, Zoltán Fülöp, Fülöp, Réka Linda   +2 more
core