Results 221 to 230 of about 12,866,090 (262)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Feasibility, Accuracy, and Acceptability of Self-Collected Dried Blood Spots for Hepatitis C Virus, Hepatitis B Virus, and SARS-CoV-2 Testing. [PDF]

Open Forum Infect Dis
Tran SS, Vanderhoff A, Saunthar A, Crespi A, Barber B, Mendlowitz AB, Gingras AC, Colwill K, Qi F, Delgado-Brand M, Mazzulli T, Kim J, Mizdrak N, Capraru C, Biondi MJ, Feld JJ.   +15 more
europepmc   +1 more source

OBESI-NET: an Italian network proposal for AI-supported obesity monitoring and precision medicine. [PDF]

Eat Weight Disord
Gambino O, Savesvki V, Manco M, D'Amico S, Ranzini MBM, Contino S, Pirrone R, Buscemi S, Vettor R.   +8 more
europepmc   +1 more source

Foreword to the focus issue: researches on materials innovation program in University of Tsukuba. [PDF]

Sci Technol Adv Mater
Yamamoto Y, Kondo T.
europepmc   +1 more source