Results 131 to 140 of about 23,716,382 (381)
Development of a prototype waste collection system /the Hydro-John/ [PDF]
Characteristics of prototype waste collection system for spacecraft ...
Murray, R. W., Reville, J. J.
core +1 more source
Increasing the Effectiveness and Efficiency of Existing Public Investments in Early Childhood Education: Recommendations to Boost Program Outcomes and Efficiency [PDF]
, 2012 Proposes ten reforms to maximize the impact of Head Start, Child Care Development Block Grants, and other existing funding streams, including working with states to align standards, improving provider quality, and enhancing data collection and ...
Donna Cooper, Kristina Costa
core
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Weeding... It Isn\u27t Just For Gardens [PDF]
, 2016 Sorry, I haven’t posted in a while; I’ve been holding out until I got to the finishing stages of the Collection Development project. Yes, that’s right, for the past couple of weeks, when I was pacing up and down the stacks on the second floor, I was not ...
Farias, Jake A.
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Science SLDM autumn 2009 - Resources [PDF]
, 2009 Collection of resource materials from the autumn 2009 secondary science subject leader development meeting (SLDM) that are designed to provide support and challenge for science departments in the implementation of Assessing Pupils' Progress (APP) and ...
core
New Frontiers In Collection Development Preparing To Meet New Standards
, 2004 This article describes the general policies which may be included in a comprehensive collection development policy, attempting to follow national guidelines. It also describes one approach to analyzing how well the library collection supports the various
Shook, Gary R.
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Collection development in digital collections
, 2019 Reports paradigm changes that occurred in the transition from physical collections to digital ones. It presents recommendations for creation and maintenance of these collections, based on the examination of specialized literature, addressing aspects of content, technical feasibility, functionality, reliability, supplier support, licensing, preservation,
Oliveira, Anastácia Freitas de +1 more
openaire +1 more source