Results 71 to 80 of about 1,694,180 (260)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

I sistemi per la gestione delle risorse elettroniche (SECONDA PARTE). Le library service platforms (LSP)

AIB Studi, 2016
L’articolo costituisce la seconda parte dello studio sui sistemi per la gestione delle risorse elettroniche e prende in esame le library service platforms (LSP), sistemi di nuova generazione che consentono di gestire l’intero ciclo di vita di tutte le ...
Sara Dinotola
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Collection Management

TCB:Technical Services in Religion & Theology, 2020
Diana Morris, Lesley Young, Christine Miskin   +2 more
openaire   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Ripensare spazi e collezioni: best practices dall'IFLA Satellite Conference "Space and collections earning their keep: transformation, technologies and re-tooling" (Parigi, 13-14 agosto 2014)

AIB Studi, 2014
L’articolo propone un resoconto critico della conferenza satellite IFLA “Space and collections earning their keep: transformation, technologies and re-tooling”, organizzata presso la Bibliothèque Universitaire des Langues et Civilisations (BULAC) di ...
Sara Dinotola
doaj   +1 more source

Design, Development, and Evaluation of the Blood Collection Management Workstation. [PDF]

Risk Manag Healthc Policy, 2022
Huang H, Yin H, Xu W, Wang Q, Xiao M, Zhao Q.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

INCloud: integrated neuroimaging cloud for data collection, management, analysis and clinical translations. [PDF]

Gen Psychiatr, 2021
Li Q, Jiang L, Qiao K, Hu Y, Chen B, Zhang X, Ding Y, Yang Z, Li C.   +8 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source