Results 51 to 60 of about 1,293,378 (269)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Silêncio compartilhado: gestos de escrita e gestos de presença

open access: yesRevista Criação & Crítica, 2015
A comunicação tem por objetivo refletir sobre a participação em um acontecimento artístico coletivo como um gesto de presença, alcançado no entrecruzamento da experiência e da escrita e possibilitando a emergência de subjetividades. A partir do texto “Cy
Luiza Crosman
doaj   +3 more sources

Collective Behavior with Endogenous Thresholds [PDF]

open access: yes, 2006
We endogenize the threshold points in Granovetter’s threshold model of collective behavior (Granovetter 1978). We do this in a simple model that combines strategic complementarity and private information in a dynamic setup with endogenous order of moves.
Xue, Jun
core   +2 more sources

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

open access: yes
Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari   +9 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Pour la mémoire de César

open access: yesCahiers Mondes Anciens
After Caesar’s funeral, already disrupted by popular excesses, a crowd gathered for several weeks on the Forum to honour the deceased and call for revenge against his murderers. This is one of the rare occurrences (apart from the food riots) where people
Mathias Nicolleau
doaj   +1 more source

Compassionate response: Intersection of religious faith and public policy [PDF]

open access: yes, 2017
Much of social work practice is rooted in compassion. Addressing compassion as a virtue, this article examines the possibilities for compassion to be more explicitly and purposefully built into actions at community and policy levels.
Collins, Mary Elizabeth   +1 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Ações coletivas civis na atualidade: dos programas de responsabilidade/compromisso social às redes de movimentos sociais

open access: yesCiências Sociais Unisinos, 2010
This paper focuses on the protagonism of the civil society by addressing the theme of the civil collective actions. Therefore, some conceptual presuppositions should be explained allowing that the subjects, and the character of these actions to be known ...
Maria da Glória Gohn
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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