Results 91 to 100 of about 5,439,813 (253)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

Youth Research Collective Life Patterns Project - Cohort 2

open access: yes
Life Patterns is an Australian Research Council funded project following the lives of young Australians since the 1990s. The project has followed two cohorts of young Australians during the last 30 years: Cohort 1 who were aged 18 in 1991 and Cohort 2 ...
Youth Research Collective
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

Modeling collective rationality : an nonparametric test on experimental data. [PDF]

open access: yes
We provide a .first nonparametric (revealed preference) test of the collective consumption model on the basis of experimental data. By using nonparametric testing tools and experimental data, we avoid the usual problems associated with parametric tests ...
Cherchye, Laurens   +2 more
core  

Youth Research Collective Life Patterns Project - Cohort 1

open access: yes
Life Patterns is an Australian Research Council funded project following the lives of young Australians since the 1990s. The project has followed two cohorts of young Australians during the last 30 years: Cohort 1 who were aged 18 in 1991 and Cohort 2 ...
Youth Research Collective
core   +1 more source

A criterion of collective behavior of bacteria

open access: yesMathematical Biosciences and Engineering, 2017
It was established in the previous works that hydrodynamic interactions between the swimmers can lead to collective motion. Its implicit evidences were confirmed by reduction in the effective viscosity. We propose a new quantitative criterion to detect such a collective behavior.
Roman Czapla, Vladimir V. Mityushev
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Collective labour supply with children [PDF]

open access: yes
We extend the collective model of household behavior to allow for the existence of public consumption. Under a separability assumption, we show that the observation of the labor supplies and the household demand for the public good allow to identify ...
Richard Blundell   +2 more
core  

Long-term tracking of social structure in groups of rats

open access: yesScientific Reports
Rodents serve as an important model for examining both individual and collective behavior. Dominance within rodent social structures can determine access to critical resources, such as food and mating opportunities.
Máté Nagy   +6 more
doaj   +1 more source

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